[CAS NO. 132907-72-3] Ramosetron Hydrochloride

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PRODUCTS SPECIFICATIONS [132907-72-3]

Catalog

AS962545

Brand

Arctom Scientific

CAS

132907-72-3

DESCRIPTION [132907-72-3]

Overview

MDL	-
Molecular Weight	315.8
Molecular Formula	C17H17N3O.HCl
SMILES	C(=O)(C=1C=2C(N(C)C1)=CC=CC2)[C@H]3CC4=C(CC3)N=CN4.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.1666 mL	15.8328 mL	31.6656 mL
5 mM	0.6333 mL	3.1666 mL	6.3331 mL
10 mM	0.3167 mL	1.5833 mL	3.1666 mL
50 mM	0.0633 mL	0.3167 mL	0.6333 mL

Description

Ramosetron Hydrochloride (YM-060) is the hydrochloride salt of ramosetron, a selective antagonist with potential antiemetic activity.

Targets

5-HT3 receptor ^[2]
(in N1E-15 cells)

0.091 nM(Ki)

In vitro

Ramosetron Hydrochloride (YM-060) has very low afinity for nicotinic and GABA receptors. In vitro studies have also demonstrated that YM060 shows low afinity for 5-HT1-like, 5-HT2, alpha-1, atpha-2, beta-1, beta-2, histamine H1 and H2 receptors. YM-060 is expected not to have 5-HT4 receptor blocking activity.

In vivo

Ramosetron is known to potently inhibit stress-induced abnormal defecation in animals. Ramosetron has potent, rapid-onset, and long-lasting inhibitory effects on CFS-induced defecation in rats, without any influence on normal defecation. The inhibitory effect of ramosetron appeared immediately after dosing and lasted for many hours.

References

[1] Hirata T, et al. J Pharmacol Sci. 2008, 106(2):264-70.
[2] Ito H, et al. J Pharmacol Exp Ther. 1992, 263(3):1127-32.

Synonyms

Methanone, (1-methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benzimidazol-6-yl]-, hydrochloride (1:1)

Methanone, (1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, monohydrochloride, (R)-

Methanone, (1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]-, monohydrochloride

YM 060

Ramosetron hydrochloride

(-)-(R)-5-[(1-Methyl-1H-indol-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole monohydrochloride

(R)-(-)-Ramosetron hydrochloride

Irribow