[CAS NO. 140158-50-5] ATPA

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PRODUCTS SPECIFICATIONS [140158-50-5]

Catalog

AS964373

Brand

Arctom Scientific

CAS

140158-50-5

DESCRIPTION [140158-50-5]

Overview

MDL	-
Molecular Weight	228.25
Molecular Formula	C10H16N2O4
SMILES	O=C(O)C(N)CC1=C(C(C)(C)C)ONC1=O

For research use only. We do not sell to patients.

Summary

ATPA is a selective glutamate receptor GluR5 activator with EC ₅₀ s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V), respectively ^[1] .

In Vitro

ATPA also activates GluR1wt, GluR1(M722S), GluR1(T700S), GluR1(T700S, M722S), GluR1(M722A) with EC ₅₀ s of 62, 4.6, 97, 14, 97 μM, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

[1] Nielsen MM, et al. The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741. Mol Pharmacol. 2003 Jan;63(1):19-25.

Synonyms

4-Isoxazolepropanoic acid, α-amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-

α-Amino-5-(1,1-dimethylethyl)-2,3-dihydro-3-oxo-4-isoxazolepropanoic acid

ATPA

2-Amino-3-[3-hydroxy-5-tert-butylisoxazol-4-yl]propanoic acid

(Rs)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid

2-Amino-3-(5-(tert-butyl)-3-hydroxyisoxazol-4-yl)propanoic acid

2-Amino-3-(5-tert-butyl-3-hydroxy-1,2-oxazol-4-yl)propanoic acid