[CAS NO. 1448867-42-2] Siremadlin(REnantiomer)

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PRODUCTS SPECIFICATIONS [1448867-42-2]

Catalog

AS965492

Brand

Arctom Scientific

CAS

1448867-42-2

DESCRIPTION [1448867-42-2]

Overview

MDL	-
Molecular Weight	555.41
Molecular Formula	C26H24Cl2N6O4
SMILES	O=C1N(C2=CC(Cl)=CN(C)C2=O)[C@H](C3=CC=C(Cl)C=C3)C4=C1N=C(C5=CN=C(OC)N=C5OC)N4C(C)C

For research use only. We do not sell to patients.

Summary

Siremadlin R Enantiomer (NVP-HDM201 R Enantiomer) is the R enantiomer of Siremadlin. Siremadlin is a potent and highly specific MDM-2/p53 inhibitor.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 56.75 mg/mL ( 102.18 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8005 mL	9.0024 mL	18.0047 mL
5 mM	0.3601 mL	1.8005 mL	3.6009 mL
10 mM	0.1800 mL	0.9002 mL	1.8005 mL

* Please refer to the solubility information to select the appropriate solvent.

Synonyms

Pyrrolo[3,4-d]imidazol-4(1H)-one, 5-(5-chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)-, (6R)-

(6R)-5-(5-Chloro-1,2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2,4-dimethoxy-5-pyrimidinyl)-5,6-dihydro-1-(1-methylethyl)pyrrolo[3,4-d]imidazol-4(1H)-one