[CAS NO. 1467047-25-1] SRS11-92
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PRODUCTS SPECIFICATIONS [1467047-25-1]
Catalog
AS965745
Brand
Arctom Scientific
CAS
1467047-25-1
DESCRIPTION [1467047-25-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 352.47 |
| Molecular Formula | C22H28N2O2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.8371 mL | 14.1856 mL | 28.3712 mL |
| 5 mM | 0.5674 mL | 2.8371 mL | 5.6742 mL |
| 10 mM | 0.2837 mL | 1.4186 mL | 2.8371 mL |
| 50 mM | 0.0567 mL | 0.2837 mL | 0.5674 mL |
Description
SRS11-92 (AA9), a Ferrostatin-1 (Fer-1) analogue, is a potent inhibitor of . SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM.
Targets
| HT-1080 ferroptotic cell death [1] (Cell-based assay) |
| 6 nM(EC50) |
In vitro
SRS11-92 is efficacious in protecting human and mouse cellular models of FRDA treated with ferric ammonium citrate (FAC) and an inhibitor of glutathione synthesis (BSO). SRS11-92 decreases the cell death associated with frataxin knockdown in healthy human fibroblasts.
References
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