[CAS NO. 146724-94-9] DETANONOate

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PRODUCTS SPECIFICATIONS [146724-94-9]

Catalog

AS965754

Brand

Arctom Scientific

CAS

146724-94-9

DESCRIPTION [146724-94-9]

Overview

MDL	-
Molecular Weight	163.18
Molecular Formula	C4H13N5O2
SMILES	O=NN(O)N(CCN)CCN

For research use only. We do not sell to patients.

Summary

DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting ^[1] ^[2] .

In Vitro

DETA NONOate (100 μM; 16 h) induces growth in an Mycobacterium abscessus complex (MABC) R morphotype by reduced glycopeptidolipid (GPL) expression of M. abscessus subspecies abscessus (Mab) ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DETA NONOate (15-150 μg/rat, i.c.v., once) exhibits a nociceptive effect in the rat formalin model ^[2] .
DETA NONOate (1 µM) reduces ischemia- or ischemia/reperfusion-induced injury to cardiac mitochondria and prevents apoptotic cell death ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats (Sixty-two, male, 200-250 g) ^[2]
Dosage:	15 or 150 μg per rat
Administration:	i.c.v., once
Result:	Accelerated the nociception in a dose-dependent manner, and this acceleration was completely abolished by Methylene Blue (HY-14536).

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H ₂ O : 50 mg/mL ( 306.41 mM ; ultrasonic and adjust pH to 9 with H ₂ O)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.1282 mL	30.6410 mL	61.2820 mL
5 mM	1.2256 mL	6.1282 mL	12.2564 mL
10 mM	0.6128 mL	3.0641 mL	6.1282 mL

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

Ethanamine, 2,2′-(2-hydroxy-2-nitrosohydrazinylidene)bis-

Ethanamine, 2,2′-(hydroxynitrosohydrazono)bis-

2,2′-(2-Hydroxy-2-nitrosohydrazinylidene)bis[ethanamine]

NOC 18

DETA/NO

DETA NONOate

Diethylamine NONOate

Diethylamine diazeniumdiolate

1,1-Bis(2-aminoethyl)-2-hydroxy-3-oxotriazane