[CAS NO. 147388-83-8] ABT-418 hydrochloride

Name: ABT-418 hydrochloride
Brand: Arctom Scientific
SKU: AS965825

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PRODUCTS SPECIFICATIONS [147388-83-8]

Distributor

Catalog

AS965825

Brand

Arctom Scientific

CAS

147388-83-8

DESCRIPTION [147388-83-8]

Overview

MDL	MFCD11045960
Molecular Weight	202.68
Molecular Formula	C9H15ClN2O
SMILES	CN1[C@H](C2=CC(C)=NO2)CCC1.Cl

For research use only. We do not sell to patients.

Summary

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease ^[1] ^[2] .

IC50 & Target

nAChRs ^[1] ^[2]

In Vivo

ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze ^[1] .
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment ^[1] .
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD ^[2] .
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model ^[2]
Dosage:	0.6 mg/kg
Administration:	Intraperitoneal injection; once daily; for two weeks
Result:	Effectively improved spatial memory.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : 11.9 mg/mL ( 58.71 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9339 mL	24.6694 mL	49.3389 mL
5 mM	0.9868 mL	4.9339 mL	9.8678 mL
10 mM	0.4934 mL	2.4669 mL	4.9339 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 100 mg/mL (493.39 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.