[CAS NO. 1494585-79-3] NaV1.7inhibitor-1

Name: NaV1.7inhibitor-1
Brand: Arctom Scientific
SKU: AS966046

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PRODUCTS SPECIFICATIONS [1494585-79-3]

Distributor

Catalog

AS966046

Brand

Arctom Scientific

CAS

1494585-79-3

DESCRIPTION [1494585-79-3]

Overview

MDL	-
Molecular Weight	435.55
Molecular Formula	C23H30FNO4S
SMILES	FC1=CC(OCC2(C)CCC3(CC3)CC2)=C(C4CC4)C=C1C(NS(C5CC5)(=O)=O)=O

For research use only. We do not sell to patients.

Summary

NaV1.7 inhibitor-1 is an efficacious voltage-gated sodium channel (NaV) 1.7 inhibitor with an IC ₅₀ of 0.6 nM for hNaV1.7, exhibits 80-fold selectivity versus hNaV1.5 ^[1] .

IC50 & Target

h Na _v 1.7

0.6 nM (IC ₅₀ )

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 229.59 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2959 mL	11.4797 mL	22.9595 mL
5 mM	0.4592 mL	2.2959 mL	4.5919 mL
10 mM	0.2296 mL	1.1480 mL	2.2959 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Sun S, Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-GatedSodium Channel (NaV) 1.7 with Potent Analgesic Activity. J Med Chem. 2019 Jan 24;62(2):908-927.