[CAS NO. 1522415-97-9] TJ191
PRODUCTS SPECIFICATIONS [1522415-97-9]
DESCRIPTION [1522415-97-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 255.38 |
| Molecular Formula | C13H21NO2S |
| SMILES | O=C(C1=C(N)SC(CCCCCCC)=C1)OC |
Summary
In Vitro
TJ191(0-100 µM; 24 hours) exhibits pronounced anti-proliferative activity in malignant cell lines, the IC
50
values are 0.13 µM, 0.13±0.08 µM, 0.26±0.19 µM, 0.22±0.11 µM, 1.5±0.02 µM, 0.32±0.086 µM, 3.1±0.5 µM, 0.26±0.16 µM in CEM, JURKAT, MOLT-3, MOLT-4, SUP-T1, MT-2, C8166 and HSB-2 cells, respectively. But has no effects in HUT-78 (IC
50
=17±10 µM) and MT-4 (IC
50
=47 ± 5 µM) cells
[1]
.
TJ191 (0.1-3 µM; 8 or 24 hours) induces CEM cell apoptosis in a concentration- and time-dependent manner. Even at 0.3 µM, TJ191 induces the maximum apoptotic rate of 80% after 24 h
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | Malignant T-cell leukemia/lymphoma cells |
| Concentration: | 0.01 µM, 0.1 µM, 1 µM, 10 µM, 100 µM |
| Incubation Time: | 24 hours |
| Result: | Exhibited inhibitory effects in drug-sensitive cells with IC 50 ranging 0.13 µM to 3.1 µM. |
Apoptosis Analysis [1]
| Cell Line: | CEM cell line |
| Concentration: | 0.1-3 µM |
| Incubation Time: | 8 or 24 hours |
| Result: | Led to cell apoptosis. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 391.57 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9157 mL | 19.5787 mL | 39.1573 mL |
| 5 mM | 0.7831 mL | 3.9157 mL | 7.8315 mL |
| 10 mM | 0.3916 mL | 1.9579 mL | 3.9157 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution