[CAS NO. 1817628-40-2] PF-06426779

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PRODUCTS SPECIFICATIONS [1817628-40-2]

Catalog

AS969919

Brand

Arctom Scientific

CAS

1817628-40-2

MDL	-
Molecular Weight	347.34
Molecular Formula	C17H18FN3O4
SMILES	O=C(C1=CC2=C(C(OC[C@H]([C@H](C)[C@@H]3F)NC3=O)=NC=C2)C=C1OC)N

For research use only. We do not sell to patients.

PF-06426779 is a potent and selective inhibitor of interleukin‑1 receptor associated kinase 4 (IRAK4) , with an IC ₅₀ of 0.3 nM ^[1] .

IRAK4

0.3 nM (IC ₅₀ )

PF-06426779 inhibits IRAK4, with an IC ₅₀ of 12.7 nM in the peripheral blood mononuclear cells (PBMCs) assay ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 100 mg/mL ( 287.90 mM ; Need ultrasonic)

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Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (5.99 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.08 mg/mL (5.99 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (5.99 mM); Clear solution

* All of the co-solvents are available by MCE.