[CAS NO. 1989-52-2] Cholesterol myristate
PRODUCTS SPECIFICATIONS [1989-52-2]
DESCRIPTION [1989-52-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 597.01 |
| Molecular Formula | C41H72O2 |
| SMILES | C[C@@]12[C@]3([H])[C@](CC=C1C[C@@H](OC(CCCCCCCCCCCCC)=O)CC2)([H])[C@@]4([H])[C@@](C)([C@]([C@H](C)CCCC(C)C)([H])CC4)CC3 |
Summary
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor , GABAA receptor , and the inward-rectifier potassium ion channel .
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate [1] . Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
Ethanol : 3.33 mg/mL ( 5.58 mM ; Need ultrasonic)
H 2 O : < 0.1 mg/mL (insoluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6750 mL | 8.3751 mL | 16.7501 mL |
| 5 mM | 0.3350 mL | 1.6750 mL | 3.3500 mL |
| 10 mM | --- | --- | --- |
References
- [1] Chen DF, et al. Cholesterol myristate suppresses the apoptosis of mesenchymal stem cells via upregulation of inhibitor of differentiation. Steroids. 2010 Dec 12;75(13-14):1119-26.
- [2] Chen DF, et al. BMP-Id pathway targeted by cholesterol myristate suppresses the apoptosis of PC12 cells. Brain Res. 2011 Jan 7;1367:33-42.
- [3] Levitan I, et al. Cholesterol binding to ion channels. Front Physiol. 2014 Feb 26;5:65.
Synonyms
