[CAS NO. 2059148-82-0] IMP-1088
PRODUCTS SPECIFICATIONS [2059148-82-0]
DESCRIPTION [2059148-82-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 453.53 |
| Molecular Formula | C25H29F2N5O |
| SMILES | CN1N=C(CN(C)C)C2=C1C=CC(C3=CC=C(F)C(F)=C3OCCC4=C(C)N(C)N=C4C)=C2 |
Summary
IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC 50 s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a K d of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection [1] .
In Vitro
IMP-1088 (1-1000 nM) prevents virus-induced cytopathic effect (CPE) in a dose-dependent manner with an IC
50
of 17 nM. IMP-1088 (125 nM) complete suppresses of new infectious virus with an IC
50
of 5.8 nM. IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h. IMP-1088 significantly inhibits production of infectious virus even when added up to 3 hours post-infection
[1]
.
IMP-1088 (50 nM) significantly less enriches multiple N-myristoylated proteins in enriched samples
[1]
.
IMP-1088 (500 nM) inhibits production of infectious rhinovirus particles by blocking virus assembly in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 h
[1]
.
IMP-1088 (0.24 nM-1 µM; for 24 hours +24 hours washout) has no long-term effect on cell viability and NMT activity fully recovers by 24 h
[1]
.
IMP-1088 potently blocks a key step in viral capsid assembly by inhibition of co-translational myristoylation of a specific virus-encoded protein (VP0). IMP-1088 blocks neither production of viral RNA, nor translation of rhinovirus polyprotein
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 220.49 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.2049 mL | 11.0246 mL | 22.0493 mL |
| 5 mM | 0.4410 mL | 2.2049 mL | 4.4099 mL |
| 10 mM | 0.2205 mL | 1.1025 mL | 2.2049 mL |