[CAS NO. 2089205-64-9] PROTACRIPKdegrader-6
PRODUCTS SPECIFICATIONS [2089205-64-9]
DESCRIPTION [2089205-64-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 889.00 |
| Molecular Formula | C43H48N6O11S2 |
| SMILES | O=S(C(C(OCCOCCOCCOCCOCC(NC1=C(CN(C2C(NC(CC2)=O)=O)C3=O)C3=CC=C1)=O)=C4)=CC(C4=NC=C5)=C5NC6=CC(N=CS7)=C7C=C6)(C(C)(C)C)=O |
Summary
IC50 & Target
|
Cereblon |
In Vitro
PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 112.49 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.1249 mL | 5.6243 mL | 11.2486 mL |
| 5 mM | 0.2250 mL | 1.1249 mL | 2.2497 mL |
| 10 mM | 0.1125 mL | 0.5624 mL | 1.1249 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 7.5 mg/mL (8.44 mM); Clear solution
References