[CAS NO. 2097509-40-3] Thalidomide-NH-PEG2-C2-NH-Boc
PRODUCTS SPECIFICATIONS [2097509-40-3]
DESCRIPTION [2097509-40-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 504.53 |
| Molecular Formula | C24H32N4O8 |
| SMILES | O=C(OC(C)(C)C)NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O |
Summary
IC50 & Target
|
Cereblon |
In Vitro
dBRD9 (0-1 μM) exerts a potent anti-proliferative effect, exceeding non-degrading probe potencies in excesses of 10 to 100 fold
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 198.20 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9820 mL | 9.9102 mL | 19.8204 mL |
| 5 mM | 0.3964 mL | 1.9820 mL | 3.9641 mL |
| 10 mM | 0.1982 mL | 0.9910 mL | 1.9820 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (4.96 mM); Suspended solution; Need ultrasonic