[CAS NO. 2102933-95-7] GSK-LSD1 dihydrochloride
PRODUCTS SPECIFICATIONS [2102933-95-7]
DESCRIPTION [2102933-95-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 289.24 |
| Molecular Formula | C14H22Cl2N2 |
| SMILES | C1(N[C@H]2[C@H](C3=CC=CC=C3)C2)CCNCC1.Cl.Cl |
5 Publications Citing Use of MCE
Summary
GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 ( LSD1 ) inhibitor with an IC 50 of 16 nM.
IC50 & Target
IC50: 16 nM (LSD1) [1]
In Vitro
GSK-LSD1 shows more than 1000 fold selectivity over other closely related FAD utilizing enzymes including LSD2, and monoamine oxidases MAO-A, MAO-B [1] . GSK-LSD1 can inhibit KDM1A/LSD1 enzyme activity. GSK-LSD1 induces the formation of LC3-II in U2OS cells. The electronic microscopy shows the formation of autophagosome with GSK-LSD1 treatment. GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 62.5 mg/mL ( 216.08 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.4573 mL | 17.2867 mL | 34.5734 mL |
| 5 mM | 0.6915 mL | 3.4573 mL | 6.9147 mL |
| 10 mM | 0.3457 mL | 1.7287 mL | 3.4573 mL |
References
- [1] Purich D. The Inhibitor Index A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads. ISBN 9781138739215
- [2] Wang Z, et al. Inhibition of H3K4 demethylation induces autophagy in cancer cell lines. Biochim Biophys Acta. 2017 Aug 8;1864(12):2428-2437.