[CAS NO. 2166487-21-2] SIRT5inhibitor1

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PRODUCTS SPECIFICATIONS [2166487-21-2]

Catalog

AS975018

Brand

Arctom Scientific

CAS

2166487-21-2

MDL	-
Molecular Weight	674.81
Molecular Formula	C31H39FN6O6S2
SMILES	O=S(N[C@@H](CCCCNC(NCCC(O)=O)=S)C(N[C@H](C(NC1CCC1)=O)CC2=CNC3=CC=CC=C23)=O)(C4=CC(F)=CC=C4)=O

For research use only. We do not sell to patients.

SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC ₅₀ of 0.11 μM.

IC50: 0.11 μM (Sirtuin) ^[1] .

SIRT5 inhibitor 1 (compound 49) is a very potent human sirtuin 5 deacylase inhibitor, with an IC ₅₀ of 0.11 μM, >100-fold from compound 1 ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 125 mg/mL ( 185.24 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (3.08 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (3.08 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2.08 mg/mL (3.08 mM); Clear solution; Need warming

* All of the co-solvents are available by MCE.