[CAS NO. 2221010-42-8] Dazcapistat

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PRODUCTS SPECIFICATIONS [2221010-42-8]

Catalog

AS976246

Brand

Arctom Scientific

CAS

2221010-42-8

DESCRIPTION [2221010-42-8]

Overview

MDL	-
Molecular Weight	395.38
Molecular Formula	C21H18FN3O4
SMILES	O=C(C(C(CC1=CC=CC=C1)NC(C2=C(C3=C(F)C=CC=C3)N=C(C)O2)=O)=O)N

For research use only. We do not sell to patients.

Summary

Dazcapistat is a potent calpain inhibitor, with IC ₅₀ s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively (patent WO2018064119A1, compound 405) ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 252.92 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5292 mL	12.6461 mL	25.2921 mL
5 mM	0.5058 mL	2.5292 mL	5.0584 mL
10 mM	0.2529 mL	1.2646 mL	2.5292 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.32 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.32 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.32 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Brad Owen BUCKMAN, et al. Calpain modulators and therapeutic uses thereof. WO2018064119A1.