[CAS NO. 2243151-81-5] Sirt2-IN-6

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PRODUCTS SPECIFICATIONS [2243151-81-5]

Catalog

AS977030

Brand

Arctom Scientific

CAS

2243151-81-5

DESCRIPTION [2243151-81-5]

Overview

MDL	-
Molecular Weight	502.59
Molecular Formula	C26H26N6O3S
SMILES	O=C(C1=CN(C)N=C1)NC2=CC=C(C=C2)OCC3=CC(NC(CSC4=NC(C)=CC(C)=N4)=O)=CC=C3

For research use only. We do not sell to patients.

Summary

Sirt2-IN-6 (compound 24a) potent and selective inhibitor of SIRT2 , with an IC ₅₀ of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer ^[1] .

IC50 & Target

SIRT2

0.815 μM (IC ₅₀ )

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Yang LL, et, al. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem. 2018 Jul 15;155:806-823.