[CAS NO. 2376990-26-8] (S,R,S)-AHPC-phenol-C4-NH2dihydrochloride
PRODUCTS SPECIFICATIONS [2376990-26-8]
DESCRIPTION [2376990-26-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 632.64 |
| Molecular Formula | C28H43Cl2N5O5S |
| SMILES | [H]Cl.[H]Cl.CC(N[C@H](C(N1C[C@@H](C[C@H]1C(NCC2=CC=C(C=C2OCCCCN)C3=C(N=CS3)C)=O)O)=O)C(C)(C)C)=O |
Summary
(S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) dihydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology [1] .
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 158.07 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5807 mL | 7.9034 mL | 15.8068 mL |
| 5 mM | 0.3161 mL | 1.5807 mL | 3.1614 mL |
| 10 mM | 0.1581 mL | 0.7903 mL | 1.5807 mL |
References