[CAS NO. 2409538-70-9] PROTAC BRD4 Degrader-5
PRODUCTS SPECIFICATIONS [2409538-70-9]
DESCRIPTION [2409538-70-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1016.67 |
| Molecular Formula | C50H62ClN9O8S2 |
| SMILES | O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C |
Summary
IC50 & Target
|
BRD4 |
In Vitro
PROTAC BRD4 Degrader-5 (Compound1; 5-100 nM; 4 hours; MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells) treatment degrades BRD4 in cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells |
| Concentration: | 5 nM, 10 nM, 50 nM, 100 nM |
| Incubation Time: | 4 hours |
| Result: | Degradation of BRD4 in MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cell. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 145 mg/mL ( 142.62 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.9836 mL | 4.9180 mL | 9.8360 mL |
| 5 mM | 0.1967 mL | 0.9836 mL | 1.9672 mL |
| 10 mM | 0.0984 mL | 0.4918 mL | 0.9836 mL |