[CAS NO. 2410557-00-3] iRucaparib-AP6
PRODUCTS SPECIFICATIONS [2410557-00-3]
DESCRIPTION [2410557-00-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 886.96 |
| Molecular Formula | C46H55FN6O11 |
| SMILES | O=C(NCC1)C2=CC(F)=CC3=C2C1=C(C4=CC=C(C=C4)CN(CCOCCOCCOCCOCCOCCOCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)C)N3 |
1 Publications Citing Use of MCE
Summary
In Vitro
iRucaparib-AP6 (0-10 μM; 24 hours) decreases PARP-1 level in a dose dependent manner, exhibits a half-maximal degrading concentration (DC
50
) of 82 nM (D
max
= 92%)
[1]
.
iRucaparib-AP6 (0-20 μM; 24 hours) induces degradation of PARP1 at low concentrations
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | Primary rat neonatal cardiomyocyte cells |
| Concentration: | 0.001 μM; 0.01 μM; 0.1 μM; 1 μM; 10 μM |
| Incubation Time: | 24 hours |
| Result: | Decreased PARP-1 level in primary rat neonatal cardiomyocyte cells. |
Western Blot Analysis [1]
| Cell Line: | Primary rat neonatal cardiomyocyte cells |
| Concentration: | 0.05 μM; 0.1 μM; 0.2 μM; 0.5 μM; 1 μM; 2 μM; 5 μM;10 μM; 20 μM |
| Incubation Time: | 24 hours |
| Result: | Induced robust PARP1 degradation at concentrations as low as 50 nM. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 50 mg/mL ( 56.37 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.1274 mL | 5.6372 mL | 11.2745 mL |
| 5 mM | 0.2255 mL | 1.1274 mL | 2.2549 mL |
| 10 mM | 0.1127 mL | 0.5637 mL | 1.1274 mL |
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1.