[CAS NO. 24345-74-2]  Azido-PEG1-azide

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PRODUCTS SPECIFICATIONS [24345-74-2]

Catalog
AS980591
Brand
Arctom Scientific
CAS
24345-74-2

DESCRIPTION [24345-74-2]

Overview

MDL-
Molecular Weight156.15
Molecular FormulaC4H8N6O
SMILES[N-]=[N+]=NCCOCCN=[N+]=[N-]

For research use only. We do not sell to patients.

Summary

Azido-PEG1-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] .


IC50 & Target

PEGs


In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Liquid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 640.41 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4041 mL 32.0205 mL 64.0410 mL
5 mM 1.2808 mL 6.4041 mL 12.8082 mL
10 mM 0.6404 mL 3.2020 mL 6.4041 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (16.01 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (16.01 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (16.01 mM); Clear solution

* All of the co-solvents are available by MCE.