[CAS NO. 290815-26-8] Avosentan

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PRODUCTS SPECIFICATIONS [290815-26-8]

Catalog

AS983111

Brand

Arctom Scientific

CAS

290815-26-8

DESCRIPTION [290815-26-8]

Overview

MDL	MFCD22124519
Molecular Weight	479.51
Molecular Formula	C23H21N5O5S
SMILES	COC1=C(OC(C(NS(C2=NC=C(C=C2)C)(=O)=O)=NC(C3=CC=NC=C3)=N4)=C4OC)C=CC=C1

For research use only. We do not sell to patients.

Summary

Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist. IC50 value: Target: ETA receptor

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00120328	Speedel Pharma Ltd.	Diabetic Nephropathy	July 2005	Phase 3

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 6.67 mg/mL ( 13.91 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0855 mL	10.4273 mL	20.8546 mL
5 mM	0.4171 mL	2.0855 mL	4.1709 mL
10 mM	0.2085 mL	1.0427 mL	2.0855 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 0.67 mg/mL (1.40 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 0.67 mg/mL (1.40 mM); Clear solution

* All of the co-solvents are available by MCE.