[CAS NO. 307986-98-7] NNC-0640

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PRODUCTS SPECIFICATIONS [307986-98-7]

Catalog

AS983390

Brand

Arctom Scientific

CAS

307986-98-7

MDL	-
Molecular Weight	573.67
Molecular Formula	C29H31N7O4S
SMILES	O=C(NC1=NN=NN1)C2=CC=C(CN(C3=CC=C(C4CCCCC4)C=C3)C(NC5=CC=CC(S(=O)(C)=O)=C5)=O)C=C2

For research use only. We do not sell to patients.

NNC-0640 is a potent human G-protein-coupled glucagon receptor (GCGR) negative allosteric modulator (NAM) with an IC ₅₀ of 69.2 nM ^[1] .

Human Glucagon Receptor ^[1]

Solid

Room temperature in continental US; may vary elsewhere.

In Vitro:

DMSO : 250 mg/mL ( 435.79 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution

* All of the co-solvents are available by MCE.