[CAS NO. 31023-24-2] Isovalerylcarnitine

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PRODUCTS SPECIFICATIONS [31023-24-2]

Catalog

AS983452

Brand

Arctom Scientific

CAS

31023-24-2

DESCRIPTION [31023-24-2]

Overview

MDL	-
Molecular Weight	245.32
Molecular Formula	C12H23NO4
SMILES	CC(C)CC(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O

For research use only. We do not sell to patients.

Summary

Isovalerylcarnitine is a product of the catabolism of L-leucine. Isovalerylcarnitine is also a selective and reversible calpain activator that induces apoptosis ^[1] ^[2] ^[3] .

IC50 & Target

Human Endogenous Metabolite

In Vitro

Isovalerylcarnitine produces an early and marked increase in phagocytosis and also in cell killing, as well as reduces proliferation, in U937 leukemic cells ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : 100 mg/mL ( 407.63 mM ; Need ultrasonic)

DMSO : 50 mg/mL ( 203.82 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0763 mL	20.3815 mL	40.7631 mL
5 mM	0.8153 mL	4.0763 mL	8.1526 mL
10 mM	0.4076 mL	2.0382 mL	4.0763 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (10.19 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (10.19 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (10.19 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-, inner salt, (2R)-

Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, isovalerate, L-

1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-(3-methyl-1-oxobutoxy)-, inner salt, (R)-

Isovalerylcarnitine

Isovaleryl L-carnitine

(R)-3-((3-Methylbutanoyl)oxy)-4-(trimethylammonio)butanoate