[CAS NO. 313964-19-1] HIF-2α-IN-3
PRODUCTS SPECIFICATIONS [313964-19-1]
DESCRIPTION [313964-19-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 335.66 |
| Molecular Formula | C12H6ClN5O5 |
| SMILES | O=[N+](C1=C(NC2=CC=C(Cl)C([N+]([O-])=O)=C2)C=CC3=NON=C31)[O-] |
Summary
HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α ( HIF-2α ), exhibits an IC 50 of 0.4 µM and a K D of 1.1 µM. Anticancer agent [1] .
In Vitro
HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 12.5 mg/mL ( 37.24 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9792 mL | 14.8960 mL | 29.7921 mL |
| 5 mM | 0.5958 mL | 2.9792 mL | 5.9584 mL |
| 10 mM | 0.2979 mL | 1.4896 mL | 2.9792 mL |