[CAS NO. 331467-03-9] 5-Iodo-indirubin-3'-monoxime

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PRODUCTS SPECIFICATIONS [331467-03-9]

Catalog

AS983753

Brand

Arctom Scientific

CAS

331467-03-9

DESCRIPTION [331467-03-9]

Overview

MDL	-
Molecular Weight	403.17
Molecular Formula	C16H10IN3O2
SMILES	O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=C(I)C=C4)=O

For research use only. We do not sell to patients.

Summary

5-Iodo-indirubin-3'-monoxime is a potent GSK-3β , CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC ₅₀ s of 9, 20 and 25 nM, respectively ^[1] .

IC50 & Target

GSK-3β

9 nM (IC ₅₀ )

Cdk5/p25

20 nM (IC ₅₀ )

Cdk1/cyclin B

25 nM (IC ₅₀ )

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 67.5 mg/mL ( 167.42 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4803 mL	12.4017 mL	24.8034 mL
5 mM	0.4961 mL	2.4803 mL	4.9607 mL
10 mM	0.2480 mL	1.2402 mL	2.4803 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.25 mg/mL (5.58 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.