[CAS NO. 37308-75-1] Flavokawain C

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [37308-75-1]

Catalog

AS984593

Brand

Arctom Scientific

CAS

37308-75-1

DESCRIPTION [37308-75-1]

Overview

MDL	-
Molecular Weight	300.31
Molecular Formula	C17H16O5
SMILES	O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=C(O)C=C2

For research use only. We do not sell to patients.

Summary

Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC ₅₀ of 12.75 μM for HCT 116 cells ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL ( 41.62 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3299 mL	16.6495 mL	33.2989 mL
5 mM	0.6660 mL	3.3299 mL	6.6598 mL
10 mM	0.3330 mL	1.6649 mL	3.3299 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 1.25 mg/mL (4.16 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.25 mg/mL (4.16 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 1.25 mg/mL (4.16 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Phang CW, et al. Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PLoS One. 2016 Feb 9;11(2):e0148775.

Synonyms

2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-

2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-, (E)-

(2E)-1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one

Flavokawain C

2′,4-Dihydroxy-4′,6′-dimethoxy-trans-chalcone

Flavokavin C

4-Hydroxyflavokawain B