[CAS NO. 47132-16-1] (E)-10-Hydroxynortriptyline
PRODUCTS SPECIFICATIONS [47132-16-1]
DESCRIPTION [47132-16-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 279.38 |
| Molecular Formula | C19H21NO |
| SMILES | OC1C2=CC=CC=C2/C(C3=CC=CC=C3C1)=C/CCNC |
Summary
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a metabolite of Nortriptyline (HY-B1417). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527A) [1] . E-10-OH-NT is about 50% as potent as nortriptyline as an inhibitor of the neuronal uptake of norepinephrine in vitro and exhibits less anticholinergic effects in man.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 3.57 mg/mL ( 12.78 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5794 mL | 17.8968 mL | 35.7935 mL |
| 5 mM | 0.7159 mL | 3.5794 mL | 7.1587 mL |
| 10 mM | 0.3579 mL | 1.7897 mL | 3.5794 mL |
References
- [1] Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.
- [2] Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.
- [3] Bertilsson L, Nordin C, Otani K, et al. Disposition of single oral doses of E-10-hydroxynortriptyline in healthy subjects, with some observations on pharmacodynamic effects. Clin Pharmacol Ther. 1986;40(3):261-267.
- [4] Dumont E, von Bahr C, Perry TL Jr, Bertilsson L. Glucuronidation of the enantiomers of E-10-hydroxynortriptyline in human and rat liver microsomes. Pharmacol Toxicol. 1987;61(5):335-341.