[CAS NO. 525-66-6] Propranolol

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PRODUCTS SPECIFICATIONS [525-66-6]

Catalog

AS986729

Brand

Arctom Scientific

CAS

525-66-6

DESCRIPTION [525-66-6]

Overview

MDL	-
Molecular Weight	259.34
Molecular Formula	C16H21NO2
SMILES	OC(COC1=C2C=CC=CC2=CC=C1)CNC(C)C

For research use only. We do not sell to patients.

9 Publications Citing Use of MCE

Summary

Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with K _i values of 1.8 nM and 0.8 nM, respectively ^[1] . Propranolol inhibits [ ³ H]-DHA binding to rat brain membrane preparation with an IC ₅₀ of 12 nM ^[2] . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy ^[3] .

IC50 & Target

β adrenergic receptor

In Vitro

Propranolol (10 ^-7 M-10 ^-3 M; 24 and 48 hours) increases the total ERK1/2 levels in a dose-dependent manner, and ERK1/2 activation is observed specifically at 10 ^-5 M in HemSCs ^[4] .
Propranolol (10 ^-9 M-10 ^-3 M; 24 and 48 hours) significant decreases cell proliferation at 10 ^-4 M propranolol after 24 hours and 10 ^-9 M propranolol after 48 hours in HemSCs ^[4] .
Propranolol (50 μM-200 μM；24 hours) increases Annexin V positivity and caspase-3 activation, rapidly induces HemSC apoptosis ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis ^[4]

Cell Line:	HemSC cells
Concentration:	10 ^-7 M-10 ^-3 M
Incubation Time:	24 and 48 hours
Result:	Increased the total ERK1/2 levels in a dose-dependent manner.

Cell Proliferation Assay ^[4]

Cell Line:	HemSC cells
Concentration:	10 ^-9 M-10 ^-3 M
Incubation Time:	24 and 48 hours
Result:	Suppressed HemSC proliferation.

Apoptosis Analysis ^[4]

Cell Line:	HemSC cells
Concentration:	50 μM, 100 μM, or 200 μM
Incubation Time:	24 hours
Result:	Induced HemSC cell death occurred via an apoptotic pathway.

In Vivo

Propranolol (orally administration; 40 mg/kg; daily) significantly reduces the vessel diameter relative to the vehicle-treated implants, and increases the number of cells that expressed phosphorylated ERK1/2 within the IH Matrigel implant ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	A xenograft mouse model of IH (infantile hemangiomas ) with HemSC cells ^[4]
Dosage:	40 mg/kg
Administration:	Orally administration; 40 mg/kg; daily
Result:	Improved vessel development in the IH mouse model that correlated with MAPK pathway activation.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01655303	Tehran University of Medical Sciences	Rapid Ventricular Response Atrial Fibrillation	February 2011	Phase 4
NCT00236561	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	Migraine\|Common Migraine\|Classic Migraine\|Headache	April 2001	Phase 3
NCT01902966	M.D. Anderson Cancer Center	Cervical Cancer	September 11, 2013	Not Applicable
NCT02789982	Assistance Publique - Hôpitaux de Paris	Post-traumatic Stress Disorder	May 2016	Phase 3
NCT01784250	CES University	Anxiety	August 2012	Phase 2
NCT00965900	Korea University	Variceal Bleeding\|Cirrhosis	September 2006	Phase 4
NCT05424016	Assistance Publique - Hôpitaux de Paris\|Agence Générale des Equipements et Produits de Santé	Hemangioblastoma of CNS\|Von Hippel-Lindau Disease	September 1, 2022	Not Applicable
NCT01988831	University Hospital, Geneva	Stages III Skin Melanoma\|Stages II Skin Melanoma\|Stage IB Skin Melanoma	June 2016	Phase 2
NCT01908972	Seoul National University Hospital	Hemangioma	June 2013	Phase 4
NCT01298284	Taipei Veterans General Hospital, Taiwan	Liver Cirrhosis\|Hepatoma	October 2009	Phase 4
NCT04533841	Ahmed mohamed fathy ismail\|Ain Shams University	Induction of Labor Affected Fetus + Newborn	February 1, 2020	Phase 2
NCT03838029	Assaf-Harofeh Medical Center\|Sheba Medical Center	Pancreatic Neoplasms	November 20, 2019	Phase 2
NCT02467400	Mayo Clinic	Osteoporosis, Age-Related	July 1, 2015	Early Phase 1
NCT02702674	Ain Shams Maternity Hospital	Poor; Labor	December 2015	Phase 3
NCT01000779	Govind Ballabh Pant Hospital	Non Cirrhotic Portal Hypertension	January 2005	Phase 3
NCT00315913	University of California, Irvine	Dysfunctional Labor	January 2004	Phase 2
NCT02853526	Zaibo Jiang\|Sun Yat-sen University	Portal Vein, Cavernous Transformation of\|Portal Vein Thrombosis\|Liver Cirrhosis\|Bleeding Esophageal Varices	July 2015	Phase 3
NCT01202110	Cedars-Sinai Medical Center	Traumatic Brain Injury	June 2010	Phase 2
NCT01074437	Seattle Children´s Hospital	Hemangioma	February 2010	Phase 2
NCT01222091	Stanford University	Hyperalgesia	February 2009	Phase 2
NCT00967226	Nancy Bauman\|Children´s National Research Institute	Hemangioma of Infancy	July 2009	Phase 2
NCT04288700	Ain Shams University	Infantile Hemangioma	October 1, 2019	Phase 4
NCT02452255	The University of Texas Medical Branch, Galveston\|National Institute of General Medical Sciences (NIGMS)\|Shriners Hospitals for Children	Burn	November 2015	Phase 2\|Phase 3
NCT02957331	University of Tennessee	Brain Injuries, Traumatic	January 2016	Phase 4
NCT03633747	Second Affiliated Hospital, School of Medicine, Zhejiang University	Hemangioma Liver	July 1, 2018	Phase 1\|Phase 2
NCT03364075	Mark Ware\|McGill University Health Centre+Research Institute of the McGill University Health Centre	Low Back Pain	September 1, 2017	Phase 2
NCT01631682	Massachusetts General Hospital	Posttraumatic Stress Disorder\|Anxiety Disorder	November 2010	Phase 4
NCT01988883	Vanderbilt University Medical Center	Postural Tachycardia Syndrome	October 2014	Early Phase 1
NCT03523650	University of Virginia	Cavernous Malformations,Cerebral and+or Spinal	February 7, 2018	Phase 1
NCT01211080	Hannover Medical School	Hemangioma	August 2008
NCT03533699	Ain Shams Maternity Hospital	Induction of Labor Affected Fetus + Newborn	October 1, 2016	Not Applicable
NCT00549120	GlaxoSmithKline	Pulmonary Disease, Chronic Obstructive	August 15, 2007	Phase 1
NCT04741698	Christiana Care Health Services	Labour;Obstructed\|Labor Dystocia	July 27, 2021	Phase 1
NCT00777218	University of South Alabama	Migraine	August 2007	Not Applicable
NCT04921982	Rennes University Hospital	Post Traumatic Stress Disorder	September 2022	Phase 2
NCT03720067	Universidade Federal do Rio de Janeiro	Cirrhosis\|Portal Hypertension\|Variceal Hemorrhage	January 25, 2019	Phase 2\|Phase 3
NCT03151681	Douglas Mental Health University Institute	Adjustment Disorders\|Posttraumatic Stress Disorder\|Trauma and Stressor Related Disorders	November 1, 2015	Phase 2\|Phase 3
NCT05419193	Beijing Tiantan Hospital	Stroke\|Vascular Accident\|Intracranial Hemorrhages\|Intracerebral Hemorrhage\|Hemorrhagic Stroke\|Stroke, Acute	July 3, 2022	Phase 3
NCT01544634	University of Dundee\|Chief Scientist Office of the Scottish Government	Asthma	April 4, 2012	Phase 2
NCT02504944	Azienda Ospedaliero, Universitaria Meyer	Retinopathy of Prematurity	July 2015	Phase 2
NCT04692844	University Medical Centre Ljubljana	Essential Tremor	August 28, 2017
NCT03237637	Postgraduate Institute of Medical Education and Research	Infantile Hemangioma	March 24, 2017	Phase 3
NCT02268357	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	Dental Anxiety	November 2014	Phase 2\|Phase 3
NCT00597389	Kent State University\|Akron Children´s Hospital\|Ohio Board of Regents	Posttraumatic Stress Disorders	February 2004	Not Applicable
NCT00888797	Sheba Medical Center\|Tel-Aviv Sourasky Medical Center\|Rabin Medical Center	Colorectal Neoplasms	January 2010	Phase 3
NCT02732678	Assistance Publique Hopitaux De Marseille	Angiosarcoma	May 2016	Phase 1\|Phase 2
NCT03152786	Wake Forest University Health Sciences\|National Cancer Institute (NCI)	Prostate Carcinoma	January 15, 2019	Phase 2
NCT04982211	Douglas Mental Health University Institute\|Canadian Institutes of Health Research (CIHR)	Trauma and Stressor Related Disorders\|Post Traumatic Stress Disorder\|Acute Stress Disorder\|Adjustment Disorders	August 1, 2021	Phase 2
NCT03108300	Ain Shams University	Malignant Soft Tissue Sarcoma	August 30, 2019	Phase 2
NCT04005365	Yijing He\|Xiangya Hospital of Central South University\|Central South University	Gastric Cancer	November 20, 2019	Phase 2
NCT01007084	University of North Carolina, Chapel Hill	Trauma	October 2009	Phase 2
NCT05256069	University of Missouri-Columbia\|American Heart Association	Vasodilation\|Hypoxia	February 2023	Early Phase 1
NCT05427474	Zagazig University	Traumatic Brain Injury	December 1, 2021	Phase 3
NCT00675714	The University of Texas Medical Branch, Galveston\|U.S. Department of Education\|National Institutes of Health (NIH)\|National Institute of General Medical Sciences (NIGMS)	Burns	January 2004	Phase 2\|Phase 3
NCT01897051	Yonsei University	Liver Cirrhosis\|Portal Hypertension	July 2013	Phase 2\|Phase 3
NCT00588965	MetroHealth Medical Center	Long QT Syndrome\|Cardiac Repolarization	August 2007	Not Applicable
NCT05525416	University of Alberta	Vasodilation\|Vasoconstriction	July 28, 2022	Not Applicable
NCT00188045	University Hospital, Angers	Alcoholic Cirrhosis	April 1995	Phase 4
NCT01087749	University of California, San Francisco	Kidney Disease	March 2010	Phase 1
NCT01074853	University of Dundee\|Chief Scientist Office of the Scottish Government	Asthma	May 2010	Phase 2
NCT04713657	Bernhard Kuhn\|University of Pittsburgh	Tetralogy of Fallot	August 15, 2022	Phase 1
NCT00465608	University Hospital, Toulouse	Post-Traumatic Stress Disorder	April 2007	Phase 2
NCT03589014	Mario Negri Institute for Pharmacological Research\|IFOM, The FIRC Institute of Molecular Oncology	Cerebral Cavernous Malformation	April 11, 2018	Phase 2
NCT02934763	Pontificia Universidad Catolica de Chile	Hyperalgesia	October 2016	Phase 4
NCT01504126	M.D. Anderson Cancer Center\|National Cancer Institute (NCI)\|Sprint for Life	Fallopian Tube Clear Cell Adenocarcinoma\|Fallopian Tube Endometrioid Adenocarcinoma\|Fallopian Tube Mucinous Adenocarcinoma\|Fallopian Tube Serous Adenocarcinoma\|Fallopian Tube Undifferentiated Carcinoma\|Ovarian Clear Cell Adenocarcinoma\|Ovarian Endometrioid Adenocarcinoma\|Ovarian Mucinous Adenocarcinoma\|Ovarian Seromucinous Carcinoma\|Ovarian Serous Adenocarcinoma\|Ovarian Undifferentiated Carcinoma\|Primary Peritoneal Serous Adenocarcinoma\|Stage II Fallopian Tube Cancer AJCC v6 and v7\|Stage II Ovarian Cancer AJCC v6 and v7\|Stage IIA Fallopian Tube Cancer AJCC v6 and v7\|Stage IIA Ovarian Cancer AJCC V6 and v7\|Stage IIB Fallopian Tube Cancer AJCC v6 and v7\|Stage IIB Ovarian Cancer AJCC v6 and v7\|Stage IIC Fallopian Tube Cancer AJCC v6 and v7\|Stage IIC Ovarian Cancer AJCC v6 and v7\|Stage III Fallopian Tube Cancer AJCC v7\|Stage III Ovarian Cancer AJCC v6 and v7\|Stage III Primary Peritoneal Cancer AJCC v7\|Stage IIIA Fallopian Tube Cancer AJCC v7\|Stage IIIA Ovarian Cancer AJCC v6 and v7\|Stage IIIA Primary Peritoneal Cancer AJCC v7\|Stage IIIB Fallopian Tube Cancer AJCC v7\|Stage IIIB Ovarian Cancer AJCC v6 and v7\|Stage IIIB Primary Peritoneal Cancer AJCC v7\|Stage IIIC Fallopian Tube Cancer AJCC v7\|Stage IIIC Ovarian Cancer AJCC v6 and v7\|Stage IIIC Primary Peritoneal Cancer AJCC v7\|Stage IV Fallopian Tube Cancer AJCC v6 and v7\|Stage IV Ovarian Cancer AJCC v6 and v7\|Stage IV Primary Peritoneal Cancer AJCC v7	March 9, 2012	Early Phase 1
NCT03245554	Central South University	Gastrointestinal Cancer	May 1, 2018	Early Phase 1
NCT00000493	National Heart, Lung, and Blood Institute (NHLBI)	Cardiovascular Diseases\|Coronary Disease\|Heart Diseases\|Myocardial Infarction\|Myocardial Ischemia	September 1977	Phase 3
NCT01791114	Rutgers University\|Rutgers, The State University of New Jersey	Insulin Sensitivity\|Obesity	January 2012	Not Applicable
NCT00611871	Wayne State University\|John D. Dingell VA Medical Center\|New York University	Posttraumatic Stress Disorders	September 2007	Phase 2
NCT01555554	University of California, San Francisco\|United States Department of Defense\|Northern California Institute of Research and Education	Post-traumatic Stress Disorder	May 2012	Not Applicable
NCT01978457	Yale University	Cocaine Dependent Subjects	October 2012	Phase 1
NCT04299438	Lisa Levine\|University of Pennsylvania	Pregnancy, Prolonged	July 14, 2020	Phase 3
NCT03038295	Guangdong Women and Children Hospital	Retinopathy of Prematurity	March 2017	Phase 2
NCT01634347	Douglas Mental Health University Institute	Substance Dependence	January 2012	Phase 2
NCT02342275	West China Hospital	Hemangioma	October 2013	Phase 3
NCT05375240	Tianjin Medical University General Hospital	Stroke\|Cerebrovascular Disorders\|Ischemic Stroke\|Brain Diseases\|Central Nervous System Diseases\|Nervous System Diseases\|Cardiovascular Diseases\|Propranolol\|Beta Blocker\|Molecular Mechanisms of Pharmacological Action\|Immunologic Factors\|Physiological Effects of Drugs	June 2022	Phase 2
NCT03323710	Military Institute of Medicine, Poland	Renal Cell Carcinoma	September 2018	Phase 2
NCT04186286	University of Calgary\|Dysautonomia International	Postural Tachycardia Syndrome	February 1, 2021	Phase 2
NCT05479123	The University of Texas Health Science Center, Houston	Infantile Hemangioma	June 23, 2022	Phase 4
NCT01847001	Columbia University	Locally Advanced Malignant Neoplasm\|Breast Cancer	October 2012	Phase 2
NCT00651235	National Taiwan University Hospital	Marfan Syndrome	February 2007	Phase 2
NCT02013492	William Carson\|Ohio State University Comprehensive Cancer Center	Male Breast Cancer\|Recurrent Melanoma\|Stage IV Breast Cancer\|Stage IV Melanoma\|Stage IV Ovarian Epithelial Cancer\|Stage IV Ovarian Germ Cell Tumor\|Unspecified Adult Solid Tumor, Protocol Specific\|Hepatocellular Carcinoma	January 21, 2014	Early Phase 1
NCT02596776	Philip Kern\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|University of Kentucky	Obese\|Normal Body Weight\|Prediabetes\|Metabolic Syndrome	March 2016	Early Phase 1
NCT01451658	Taipei Veterans General Hospital, Taiwan	Gastroesophageal Varices Hemorrhage\|Hepatocellular Carcinoma	December 2009	Phase 4
NCT02790736	New York State Psychiatric Institute	Social Anxiety Disorder	June 2016	Phase 4
NCT01263197	Eli Lilly and Company	Major Depressive Disorder	December 2010	Phase 1
NCT00688805	National Institute on Drug Abuse (NIDA)\|National Institutes of Health Clinical Center (CC)	Cocaine Dependence	December 12, 2007	Phase 1
NCT04113187	University Hospital, Bordeaux\|AMRO-HHT-France - Association Maladie de Rendu-Osler	Hereditary Hemorrhagic Telangiectasia\|Osler Weber Rendu Disease	June 23, 2020	Phase 3
NCT00709735	Massachusetts General Hospital\|VA Office of Research and Development	Posttraumatic Stress Disorder	May 2007	Phase 4
NCT01238471	Rambam Health Care Campus\|Hadassah Medical Organization\|Laniado Hospital\|Nazareth Hospital	Retinopathy of Prematurity	May 2010	Phase 1\|Phase 2
NCT01007994	Northwell Health\|Children´s Hospital of Philadelphia	Hypertension Secondary to Kidney Transplant	November 2009	Phase 2\|Phase 3
NCT05312255	Roswell Park Cancer Institute	Plasma Cell Myeloma\|Recurrent Plasma Cell Myeloma\|Refractory Plasma Cell Myeloma\|Smoldering Plasma Cell Myeloma	June 28, 2022	Not Applicable
NCT00016666	National Institute of Mental Health (NIMH)\|National Institutes of Health Clinical Center (CC)	Seasonal Affective Disorder\|Healthy	May 21, 2001	Phase 2
NCT00000197	National Institute on Drug Abuse (NIDA)\|University of Pennsylvania	Cocaine-Related Disorders	January 1987	Phase 2
NCT02477384	West China Hospital	Portal Hypertension	June 2015	Not Applicable
NCT00916721	Massachusetts General Hospital	Smoking Cessation	April 2008	Phase 3
NCT03152175	Douglas Mental Health University Institute\|Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail	Trauma and Stressor Related Disorders\|Post-traumatic Stress Disorders\|Adjustment Disorders\|Acute Stress Disorder	March 30, 2017	Phase 2
NCT00158132	University of Pennsylvania\|National Institute on Drug Abuse (NIDA)	Cocaine-Related Disorders	September 1999	Phase 2
NCT05195996	Menoufia University	Trauma, Brain	April 1, 2021	Phase 4
NCT04580342	Ahmed talaat ahmed aly\|Assiut University	Hypotension	October 15, 2020	Phase 2
NCT00766805	Govind Ballabh Pant Hospital	Portal Hypertension	October 2002	Not Applicable
NCT01077921	Laura M. De Castro, MD\|National Heart, Lung, and Blood Institute (NHLBI)\|Duke University	Sickle Cell Disease	June 2010	Phase 2
NCT04467086	Ottawa Hospital Research Institute\|Hamilton Health Sciences Corporation\|Toronto General Hospital\|University Health Network, Toronto\|The Ottawa Hospital\|McMaster University\|Sinai Health System	Mechanical Ventilation\|Sedation\|Critical Illness\|COVID	December 11, 2020	Phase 3
NCT02495883	University of California, San Diego\|National Institute of Neurological Disorders and Stroke (NINDS)	Essential Tremor\|Tremor	December 2013	Phase 4
NCT00830362	Medical University of South Carolina\|National Institute on Drug Abuse (NIDA)	Cocaine Dependence	February 2009	Phase 2
NCT00158262	Massachusetts General Hospital\|National Institute of Mental Health (NIMH)	Post-Traumatic Stress Disorder	September 2004	Phase 4
NCT02179775	Shiraz University of Medical Sciences	Migraine Headache\|Gastric Diseases	July 2014	Not Applicable
NCT00759005	National Institute on Drug Dependence, China	Heroin Dependence\|Learning and Memory	March 2007	Not Applicable
NCT05451043	AHS Cancer Control Alberta	Pancreatic Cancer\|Hepatocellular Cancer\|Biliary Tract Cancer\|Cholangiocarcinoma	October 1, 2022	Phase 2
NCT01127568	Douglas Mental Health University Institute\|Massachusetts General Hospital\|Harvard University\|McGill University\|US Department of Veterans Affairs	Stress Disorders, Post-Traumatic	February 2010	Phase 2\|Phase 3
NCT00862095	Madigan Army Medical Center\|U.S. Army Medical Research and Development Command	Headache	June 2008	Phase 4
NCT02385422	Shanghai Zhongshan Hospital	Liver Cirrhosis\|Esophageal and Gastric Varices\|Hemorrhage	March 2015	Phase 4
NCT03094234	West China Hospital	Portal Hypertension	April 28, 2017	Not Applicable
NCT05106179	Center for Vascular Pathology, Moscow	Spinal Tumor\|Spinal Hemangioma\|Beta Blocker Toxicity	December 2021	Phase 4
NCT00889096	University Medicine Greifswald	Memory\|Heart Rate\|Skin Electric Conductance\|Amylase\|Propanolol		Phase 1
NCT00884663	Norwegian University of Science and Technology\|AstraZeneca\|St. Olavs Hospital\|Kragerø Tablettproduksjon as, Norway	Migraine Without Aura\|Migraine With Aura\|Chronic Migraine	April 2009	Phase 2\|Phase 3
NCT03251326	New York State Psychiatric Institute\|National Institute on Drug Abuse (NIDA)	Cannabis\|Post Traumatic Stress Disorder	October 2015	Phase 1\|Phase 2
NCT04406870	Shanghai Children´s Medical Center	Hemangioendothelioma of Liver	July 2020	Phase 4
NCT02740166	Kaohsiung Veterans General Hospital.	Esophageal Varices	June 2013	Phase 4
NCT02871349	University of Missouri-Columbia\|United States Department of Defense	Autism Spectrum Disorder	August 2016	Early Phase 1
NCT00645450	VA Office of Research and Development	Posttraumatic Stress Disorders	April 2008	Phase 4
NCT00910689	Ohio University\|National Institute of Neurological Disorders and Stroke (NINDS)\|Merck Sharp & Dohme LLC\|GlaxoSmithKline	Migraine Headache	July 2001	Phase 4
NCT01308944	Washington University School of Medicine	Invasive Epithelial Ovarian Cancer\|Primary Peritoneal Carcinoma\|Fallopian Tube Cancer	August 2010	Phase 1
NCT05251610	Darlington-Peter Chibuzor Ugoji\|Alex Ekwueme Federal University Teaching Hospital	Duration of Labor	November 2, 2020	Not Applicable
NCT01058317	Massachusetts Eye and Ear Infirmary	Recurrent Respiratory Papillomatosis	January 2010	Phase 2\|Phase 3
NCT01061190	Wilhelm Haverkamp\|German Federal Ministry of Education and Research\|Charite University, Berlin, Germany	Stroke	January 2010	Phase 2\|Phase 3
NCT05587361	University of Oklahoma\|Oklahoma State University Center for Health Sciences\|Duke University\|National Institute on Drug Abuse (NIDA)\|National Institutes of Health (NIH)	Tobacco Use Disorder\|Nicotine Dependence\|Cigarette Smoking	November 1, 2022	Phase 4
NCT05561751	GPCR Therapeutics, Inc.	Multiple Myeloma	November 30, 2022	Phase 2
NCT04985344	University Hospital, Toulouse	PTSD	September 2021	Phase 3
NCT00905996	Govind Ballabh Pant Hospital	Cirrhosis	August 2006	Not Applicable
NCT03348683	Icahn School of Medicine at Mount Sinai	Induction of Labor Affected Fetus + Newborn	December 11, 2017	Phase 2
NCT03919461	Assaf-Harofeh Medical Center\|Sheba Medical Center\|Rabin Medical Center\|Tel-Aviv Sourasky Medical Center\|Rambam Health Care Campus\|HaEmek Medical Center, Israel	Colorectal Neoplasms	February 28, 2019	Phase 2
NCT04493489	Central South University	Bladder Cancer	September 6, 2020	Phase 2
NCT02032758	Mayo Clinic	Occupational; Cramp(s)	January 2014	Phase 4
NCT03309943	Duke University\|National Institutes of Health (NIH)\|National Institute on Drug Abuse (NIDA)	Cigarette Smoking	January 16, 2018	Phase 4
NCT05189977	Otsuka Pharmaceutical Development & Commercialization, Inc.\|Iqvia Pty Ltd	Post-traumatic Stress Disorder (PTSD)	August 22, 2022	Phase 1
NCT00934947	University of North Carolina, Chapel Hill	Burns\|Pain	July 2009	Phase 2
NCT01059396	Fundació Institut de Recerca de l´Hospital de la Santa Creu i Sant Pau	Portal Hypertension Gastropathy\|Esophageal Varices\|Spontaneous Bacterial Peritonitis\|Hepatic Encephalopathy\|Ascites	January 28, 2010	Phase 4
NCT01458600	Mikael Lantz\|Region Skane	Graves´ Disease	September 2006	Phase 4
NCT01322048	Vanderbilt University\|Vanderbilt Institute for Clinical and Translational Research (CTSA)\|Eastern Association for the Surgery of Trauma (EAST)\|Vanderbilt University Medical Center	Brain Injuries\|Craniocerebral Trauma\|Trauma, Nervous System\|Traumatic Brain Injury	August 2011	Phase 2
NCT04833218	Minia University	Traumatic Brain Injury	January 31, 2020	Early Phase 1
NCT01950520	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|National Institutes of Health Clinical Center (CC)	Healthy Volunteers	February 7, 2014	Phase 2
NCT02505971	The Hospital for Sick Children	Infantile Hemangioma	September 2015	Phase 3
NCT02171988	Seoul National University Hospital	Postural Orthostatic Tachycardia Syndrome	March 2014	Phase 4
NCT01705392	Haukeland University Hospital\|The Norwegian Melanoma Group\|Norwegian Cancer Society	Metastatic Malignant Melanoma\|Unresectable Malignant Melanoma	January 2013	Phase 2
NCT01512173	Pierre Fabre Dermatology	Infantile Hemangioma	January 2012	Phase 2
NCT03171805	West China Hospital	Liver Cirrhoses\|Portal Hypertension\|Gastric Varix	June 1, 2017	Not Applicable
NCT00000492	National Heart, Lung, and Blood Institute (NHLBI)	Arrhythmia\|Cardiovascular Diseases\|Coronary Disease\|Death, Sudden, Cardiac\|Heart Diseases\|Myocardial Infarction\|Myocardial Ischemia\|Ventricular Fibrillation	September 1977	Phase 3
NCT02511483	McGill University Health Centre+Research Institute of the McGill University Health Centre	Postoperative Pain	May 18, 2015	Phase 2
NCT00744185	University Hospital, Bordeaux	Hemangioma, Capillary	October 2008	Phase 2\|Phase 3
NCT00673309	The University of Texas Medical Branch, Galveston\|National Institute of General Medical Sciences (NIGMS)	Burns	July 2000	Phase 2\|Phase 3
NCT02977000	Huiqing Sun\|Zhengzhou Children´s Hospital, China	Retinopathy of Prematurity	May 2016	Not Applicable
NCT02264093	Boehringer Ingelheim	Healthy	November 1999	Phase 1
NCT04848519	Emory University\|National Cancer Institute (NCI)	Locally Advanced Bladder Urothelial Carcinoma\|Locally Advanced Renal Pelvis Urothelial Carcinoma\|Locally Advanced Ureter Urothelial Carcinoma\|Locally Advanced Urethral Urothelial Carcinoma\|Locally Advanced Urothelial Carcinoma\|Metastatic Bladder Urothelial Carcinoma\|Metastatic Renal Pelvis Urothelial Carcinoma\|Metastatic Ureter Urothelial Carcinoma\|Metastatic Urethral Urothelial Carcinoma\|Metastatic Urothelial Carcinoma\|Stage IV Bladder Cancer AJCC v8\|Stage IV Renal Pelvis Cancer AJCC v8\|Stage IV Ureter Cancer AJCC v8\|Stage IV Urethral Cancer AJCC v8	May 20, 2021	Phase 2
NCT03882255	Janssen Pharmaceutica N.V., Belgium	Healthy	March 20, 2019	Phase 1
NCT00770484	Vanderbilt University	Orthostatic Intolerance\|Postural Tachycardia Syndrome	November 2008	Not Applicable
NCT00647816	Mylan Pharmaceuticals Inc\|MylanPharma	Healthy	September 2005	Phase 1
NCT03609307	Shahid Beheshti University of Medical Sciences	Age Related Macular Degeneration	September 2018	Phase 2\|Phase 3
NCT04682184	Eli Lilly and Company	Healthy	January 27, 2021	Not Applicable
NCT00069355	National Institute of Mental Health (NIMH)\|National Institutes of Health Clinical Center (CC)	Stress Disorders, Traumatic, Acute	September 2003	Phase 2
NCT05463614	Shandong University	Arrhythmia	February 1, 2019
NCT04208594	Alexandria University	Ivabradine\|Propranolol\|Hypotensive Anesthesia	December 11, 2019	Not Applicable
NCT02350985	Haseki Training and Research Hospital	Vestibular Migraine	January 2014	Phase 4
NCT00654290	Shiraz University of Medical Sciences	Atrial Fibrillation	March 2007	Not Applicable
NCT03161964	Anu Sharma\|University of Utah	Type 1 Diabetes Mellitus	October 19, 2017	Phase 2
NCT01299753	Sunnybrook Health Sciences Centre	Burns	February 2011	Not Applicable
NCT04508244	Hamad Medical Corporation	Trauma\|Brain Injuries\|Stress Reaction\|Beta Blockers\|Troponin	December 29, 2020	Phase 4
NCT03401515	Ain Shams University	Traumatic Brain Injury	October 1, 2016	Phase 4
NCT03049306	Johns Hopkins University\|National Heart, Lung, and Blood Institute (NHLBI)	Obstructive Sleep Apnea	February 15, 2017	Phase 2
NCT01070225	University of Dundee\|NHS Tayside	Asthma	March 2010	Phase 4
NCT02256722	Boehringer Ingelheim	Healthy	October 2005	Phase 1
NCT01343329	Johns Hopkins University	Traumatic Brain Injury\|Dysautonomia	July 2011	Phase 1\|Phase 2
NCT00865215	Actavis Inc.	Healthy	April 2005	Phase 1
NCT01069159	Mela, Mansfield, M.D.	Traumatic Memory\|Posttraumatic Stress Disorder	February 2010	Not Applicable
NCT00251602	National Institute on Aging (NIA)\|National Institutes of Health Clinical Center (CC)	Healthy	March 2003	Phase 1
NCT00493480	Hvidovre University Hospital	Cirrhosis\|Portal Hypertension	September 2003	Phase 3
NCT03029845	University of Utah	Fibromyalgia Pain	January 2017	Phase 1
NCT03783065	Nanfang Hospital of Southern Medical University\|Shunde Hospital, Southern Medical University\|Xingtai People´s Hospital\|Beijing 302 Hospital\|LanZhou University	Portal Hypertension\|Variceal Rebleeding	January 2, 2019	Not Applicable
NCT02014454	Azienda Ospedaliero, Universitaria Meyer	Retinopathy of Prematurity	November 2013	Phase 2
NCT00332904	Hvidovre University Hospital	Liver Cirrhosis\|Portal Hypertension	August 2006	Phase 4
NCT01060111	Janssen Korea, Ltd., Korea	Migraine	July 2006	Phase 4
NCT03254186	Emory University\|Atlanta Clinical and Translational Science Institute	Tardive Dyskinesia	September 18, 2017	Phase 2\|Phase 3
NCT01902810	The University of Texas Medical Branch, Galveston\|United States Department of Defense\|American Burn Association	Burn	July 2013	Phase 2\|Phase 3
NCT02111369	Emory University	Essential Vocal Tremor\|Essential Voice Tremor\|Essential Tremor\|Voice Tremor\|Vocal Tremor	May 2014	Phase 4
NCT04074473	Taipei Veterans General Hospital, Taiwan	Acute Kidney Injury\|Cirrhosis\|Esophageal Varices	April 13, 2015	Phase 4
NCT02414451	University of Missouri-Columbia	Autism	September 2016	Not Applicable
NCT00093860	National Institute of Neurological Disorders and Stroke (NINDS)\|National Institutes of Health Clinical Center (CC)	Syncope	October 2004	Phase 2
NCT04208776	Institute of Liver and Biliary Sciences, India	Decompensated Cirrhosis\|Severe Ascites	February 4, 2020	Not Applicable
NCT02437383	University of North Carolina, Chapel Hill\|University of Florida\|Rho, Inc.\|National Institutes of Health (NIH)\|National Institute of Dental and Craniofacial Research (NIDCR)\|State University of New York at Buffalo	Temporomandibular Disorders	August 20, 2015	Phase 2
NCT00687700	Theravance Biopharma\|GlaxoSmithKline	Pulmonary Disease, Chronic Obstructive	March 10, 2008	Phase 1
NCT04651049	Qilu Hospital of Shandong University	Infantile Haemangiomas	July 15, 2010
NCT00772031	Anne Lindblad\|National Institute of Neurological Disorders and Stroke (NINDS)\|Ortho-McNeil Janssen Scientific Affairs, LLC\|The Emmes Company, LLC	Chronic Migraine	October 2008	Phase 3
NCT01349439	Douglas Mental Health University Institute\|Canadian Institutes of Health Research (CIHR)	Posttraumatic Stress Disorder	March 2011	Phase 2
NCT00772057	Govind Ballabh Pant Hospital	Cirrhosis	October 2004	Not Applicable
NCT03893617	Dana Bovbjerg\|National Cancer Institute (NCI)\|University of Pittsburgh	DNA Damage\|Psychological Stress	October 5, 2017	Phase 1
NCT00060866	National Institute of Neurological Disorders and Stroke (NINDS)\|National Institutes of Health Clinical Center (CC)	Neurocardiogenic Syncope	May 2003	Phase 4
NCT02428205	University of Missouri-Columbia\|Autism Science Foundation	Autism	April 2015	Not Applicable
NCT01970748	Taipei Veterans General Hospital, Taiwan	Bleeding Esophageal Varices\|Hepatocellular Carcinoma	August 2009	Phase 4
NCT03474614	St. Joseph´s Hospital and Medical Center, Phoenix	Cerebral Cavernous Malformations	January 24, 2018	Phase 2
NCT03079921	University of Pennsylvania\|National Institutes of Health (NIH)\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Type1diabetes\|Hypoglycemia\|Hypoglycemia Unawareness\|Islet Cell Transplantation	January 20, 2017	Early Phase 1
NCT04047355	Rutgers, The State University of New Jersey\|New Jersey Governor´s Council for Medical Research and Treatment of Autism\|New York State Institute for Basic Research	Autism Spectrum Disorder\|Developmental Disability\|Aggression\|Self-Injurious Behavior\|Challenging Behavior	January 1, 2021	Phase 2
NCT01072045	University of Sao Paulo\|University of Sao Paulo General Hospital	Hemangioma	January 2010	Phase 2
NCT02631694	VU University of Amsterdam	Panic Disorder	April 2016	Phase 2
NCT02012777	University of Miami\|Duke University	Sickle Cell Disease	June 2010	Phase 1
NCT00935805	Hospital de Clinicas de Porto Alegre\|Conselho Nacional de Desenvolvimento Científico e Tecnológico\|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil	Diabetes Mellitus\|Arterial Hypertension	July 2006
NCT03388957	Damascus University	Extrusion of Tooth	July 30, 2018	Not Applicable
NCT03588754	Yale University\|National Institute on Alcohol Abuse and Alcoholism (NIAAA)	Alcohol Drinking	September 15, 2018	Phase 2
NCT01713556	University Hospital, Toulouse	Post-traumatic Stress Disorder	November 2012	Phase 2
NCT03434444	Samuel Lunenfeld Research Institute, Mount Sinai Hospital	Postpartum Hemorrhage	September 8, 2017	Not Applicable
NCT00390546	University of British Columbia\|The Hospital for Sick Children\|University of Utah	Supraventricular Tachycardia	October 2006	Phase 3
NCT03083431	University of Zurich\|Ankara University\|University Hospital Tuebingen	Retinopathy of Prematurity	September 22, 2022	Phase 2
NCT01205074	Hadassah Medical Organization\|Exalenz Bioscience LTD.	Healthy Subjects\|Chronic Liver Disease\|Cirrhosis	September 2010	Phase 2\|Phase 3
NCT00864747	Actavis Inc.	Healthy	May 2005	Phase 1
NCT01094574	Martin Angst\|Stanford University	Pain Measurement	January 2010	Not Applicable
NCT01055171	Medical University of South Carolina\|National Institute on Alcohol Abuse and Alcoholism (NIAAA)	Alcohol Dependence\|PTSD	January 2010	Phase 2
NCT04682158	Roswell Park Cancer Institute	Esophageal Adenocarcinoma	April 1, 2021	Phase 2
NCT00902161	Merck Sharp & Dohme LLC	Type 2 Diabetes Mellitus	May 2009	Phase 1
NCT02649335	Postgraduate Institute of Medical Education and Research	Ascites	July 2015	Phase 3
NCT01535495	University of Wisconsin, Madison	Proliferative Diabetic Retinopathy	February 2012	Phase 1
NCT01893541	Federal University of São Paulo	CIRRHOSIS\|ESOPHAGEAL VARICES	June 2008	Phase 4
NCT04950426	Centre Hospitalier Henri Laborit	Fibromyalgia Syndrome\|Posttraumatic Stress Disorder	August 13, 2021	Phase 2
NCT01079715	Azienda Ospedaliero, Universitaria Meyer\|Ospedale Maggiore Policlinico Mangiagalli e Regina Elena	Retinopathy of Prematurity	January 2010	Phase 2\|Phase 3
NCT02595996	Columbia University	Primary Lymphedema	June 7, 2017	Phase 2
NCT05085782	Université de Sherbrooke	Chronic Low-back Pain\|Fibromyalgia	February 7, 2022	Phase 2
NCT00262470	Satish R. Raj\|National Institutes of Health (NIH)\|Vanderbilt University Medical Center	Tachycardia\|Chronic Orthostatic Intolerance	April 1997	Phase 1\|Phase 2
NCT00652600	Par Pharmaceutical, Inc.\|SFBC Anapharm	To Determine Bioequivalence Under Fed Conditions	September 2005	Phase 1
NCT01957449	The University of Texas Medical Branch, Galveston\|Shriners Hospitals for Children	Burn	December 2013	Phase 2\|Phase 3
NCT00337740	University of Padova	Liver Cirrhosis\|Esophageal Varices		Phase 3
NCT01056341	Pierre Fabre Dermatology	Infantile Hemangioma	January 2010	Phase 2\|Phase 3
NCT04837261	Tampere University Hospital\|Helsinki University Central Hospital\|Kuopio University Hospital\|Oulu University Hospital\|Turku University Hospital	Supraventricular Tachycardia	April 15, 2021
NCT02420223	Medical College of Wisconsin\|University of California, Los Angeles	Multiple Myeloma	July 17, 2015	Phase 2
NCT03379181	University Hospital, Basel, Switzerland	Hyperthyroidism	July 18, 2017	Phase 4
NCT01284868	Astellas Pharma Inc	Healthy Volunteers\|Pharmacodynamics of Mirabegron	July 2009	Phase 1
NCT00356187	Denver Health and Hospital Authority\|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	Trauma	February 15, 2006	Phase 2
NCT04421209	Duke University\|Foundation for Anesthesia Education and Research	Lumbar Disc Disease\|Spinal Fusion\|Degenerative Disc Disease	December 2020	Phase 2
NCT03270644	Eli Lilly and Company	Healthy	August 31, 2017	Phase 1
NCT02104011	University Hospital, Bordeaux	Renal Angiomyolipomas\|Tuberous Sclerosis	May 22, 2015	Phase 2
NCT01298271	Taipei Veterans General Hospital, Taiwan	Bleeding Gastric Varices\|Liver Cirrhosis	April 2010	Phase 4
NCT02808611	Kristian Kjær Petersen\|Aalborg University	Healthy Subjects	July 2016	Not Applicable
NCT04684667	Assiut University	Infantile Hemangioma	January 1, 2021	Phase 2
NCT05219799	University of Missouri-Columbia	Obesity\|Vasodilation\|Healthy	February 2023	Early Phase 1
NCT02897986	Assistance Publique Hopitaux De Marseille	Pediatric Cancer	January 2017	Phase 1
NCT02962947	Azienda Sanitaria di Firenze	Melanoma	June 2017	Phase 2\|Phase 3
NCT00888784	Govind Ballabh Pant Hospital	Cirrhosis	August 2006	Not Applicable
NCT02620579	Duke University\|National Institutes of Health (NIH)\|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)	Shoulder Pain	January 2016	Phase 2
NCT04518124	The Netherlands Cancer Institute\|Anticancer Fund, Belgium	Angiosarcoma	December 27, 2019	Phase 2
NCT00653120	Par Pharmaceutical, Inc.\|SFBC Anapharm	To Determine Bioequivalence Under Fasting Conditions	May 2005	Phase 2
NCT00647608	Mylan Pharmaceuticals Inc\|MylanPharma	Healthy	September 2005	Phase 1
NCT03384836	Roswell Park Cancer Institute	Stage IIIC Cutaneous Melanoma AJCC v7\|Stage IV Cutaneous Melanoma AJCC v6 and v7	January 31, 2018	Phase 1\|Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 385.59 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8559 mL	19.2797 mL	38.5594 mL
5 mM	0.7712 mL	3.8559 mL	7.7119 mL
10 mM	0.3856 mL	1.9280 mL	3.8559 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-

2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-

1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol

1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol

Propranolol

β-Propranolol

1-(1-Naphthyloxy)-3-(isopropylamino)-2-propanol

Proprasylyt

Reducor

Betalong

dl-Propranolol

(±)-Propranolol

Racemic propranolol

DL-Propranolol

AY 64043

Euprovasin

Innopran XL

3-(Naphth-1-yloxy)-1-(isopropylamino)propan-2-ol

1-Isopropylamino-3-naphthalen-1-yloxypropan-2-ol

[2-Hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine

1-(Naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol