[CAS NO. 55750-05-5] Caroverine hydrochloride
PRODUCTS SPECIFICATIONS [55750-05-5]
DESCRIPTION [55750-05-5]
Overview
| MDL | MFCD01684929 |
|---|---|
| Molecular Weight | 401.93 |
| Molecular Formula | C22H28ClN3O2 |
| SMILES | O=C1N(CCN(CC)CC)C2=C(C=CC=C2)N=C1CC3=CC=C(OC)C=C3.[H]Cl |
Summary
Caroverine (Tinnex) hydrochloride is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor . Caroverine hydrochloride is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action. Caroverine hydrochloride can be used for the research of inner ear tinnitus [1] [2] [3] .
In Vitro
Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) and noradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat [4] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure [4] |
| Dosage: | 1.44 mg/rat |
| Administration: | 20 mg/mL; s.c. 1.0 mL/h for 72 h |
| Result: | Significantly protected the cochlea against impulse noise trauma. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL ( 248.80 mM ; Need ultrasonic)
H 2 O : 20 mg/mL ( 49.76 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4880 mL | 12.4400 mL | 24.8800 mL |
| 5 mM | 0.4976 mL | 2.4880 mL | 4.9760 mL |
| 10 mM | 0.2488 mL | 1.2440 mL | 2.4880 mL |
References
- [1] Chen Z, et, al. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs. Audiol Neurootol. Jan-Feb 2003;8(1):49-56.
- [2] Denk DM, et, al. Caroverine in tinnitus treatment. A placebo-controlled blind study. Acta Otolaryngol. 1997 Nov;117(6):825-30.
- [3] Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8.
- [4] Duan M, et, al. Low-dose, long-term caroverine administration attenuates impulse noise-induced hearing loss in the rat. Acta Otolaryngol. 2006 Dec;126(11):1140-7.