[CAS NO. 73069-27-9] Praeruptorin A

Name: Praeruptorin A
Brand: Arctom Scientific
SKU: AS990136

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PRODUCTS SPECIFICATIONS [73069-27-9]

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Catalog

AS990136

Brand

Arctom Scientific

CAS

73069-27-9

DESCRIPTION [73069-27-9]

Overview

MDL	-
Molecular Weight	386.40
Molecular Formula	C21H22O7
SMILES	C/C=C(C)\C(O[C@H]1[C@@H](OC(C)=O)C2=C3C(C=CC(O3)=O)=CC=C2OC1(C)C)=O

For research use only. We do not sell to patients.

Summary

Praeruptorin A is a main bioactive constituent of Peucedanum praeruptorum (also known as Bai-Hua Qian Hu). Praeruptorin A exerts anti-inflammatory effects in vitro through inhibition of NF-κB activation ^[1] .

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL ( 86.26 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5880 mL	12.9400 mL	25.8799 mL
5 mM	0.5176 mL	2.5880 mL	5.1760 mL
10 mM	0.2588 mL	1.2940 mL	2.5880 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.47 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (6.47 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.47 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Zhou X, et al. Effects of praeruptorin A and praeruptorin C, a racemate isolated from , on MRP2 through the CAR pathway. Planta Med. 2013 Nov;79(17):1641-7.