[CAS NO. 799279-80-4] Sofiniclin

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PRODUCTS SPECIFICATIONS [799279-80-4]

Catalog

AS991069

Brand

Arctom Scientific

CAS

799279-80-4

DESCRIPTION [799279-80-4]

Overview

MDL	-
Molecular Weight	244.12
Molecular Formula	C10H11Cl2N3
SMILES	ClC1=C(Cl)C=C(N2C[C@]3([H])CN[C@]3([H])C2)C=N1

For research use only. We do not sell to patients.

Summary

Sofiniclin (ABT 894), an agonist of nicotinic acetylcholine receptor (nAChR) , is used as a potential non-stimulant research for attention-deficit/hyperactivity disorder (ADHD) ^[1] ^[2] .

In Vitro

Sofiniclin is more potent than ABT-089 at both receptor subtypes, with K _i values of 1.9 nM for ¹²⁵ I-α-conotoxinMII binding and of 1.3 nM for ¹²⁵ I-epibatidine binding ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sofiniclin (0.001 to 0.10 mg/kg, p.o.) produces significant reductions in LIDs compared to vehicle monkey ^[1] . Sofiniclin (0.1 mg/kg) does not decrease LIDs in monkeys with severe nigrostriatal damage ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00548925	AbbVie (prior sponsor, Abbott)\|AbbVie	Diabetic Neuropathic Pain	November 2007	Phase 2
NCT00429091	Abbott	Attention-Deficit+Hyperactivity Disorder\|ADHD	January 2007	Phase 2
NCT00507936	AbbVie (prior sponsor, Abbott)\|AbbVie	Diabetic Neuralgia\|Diabetic Neuropathies\|Diabetic Neuropathy, Painful\|Diabetic Polyneuropathy\|Neuralgia, Diabetic	August 2007	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 35.71 mg/mL ( 146.28 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0963 mL	20.4817 mL	40.9635 mL
5 mM	0.8193 mL	4.0963 mL	8.1927 mL
10 mM	0.4096 mL	2.0482 mL	4.0963 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (8.52 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (8.52 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (8.52 mM); Clear solution

* All of the co-solvents are available by MCE.