[CAS NO. 86770-68-5] Azido-PEG5-alcohol
PRODUCTS SPECIFICATIONS [86770-68-5]
DESCRIPTION [86770-68-5]
Overview
| MDL | MFCD20134131 |
|---|---|
| Molecular Weight | 263.29 |
| Molecular Formula | C10H21N3O5 |
| SMILES | OCCOCCOCCOCCOCCN=[N+]=[N-] |
Summary
Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1] . Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [2] .
IC50 & Target
|
PEGs |
Non-cleavable |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker
[1]
.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References