[CAS NO. 86770-69-6] Azido-PEG6-alcohol
PRODUCTS SPECIFICATIONS [86770-69-6]
DESCRIPTION [86770-69-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 307.34 |
| Molecular Formula | C12H25N3O6 |
| SMILES | OCCOCCOCCOCCOCCOCCN=[N+]=[N-] |
Summary
Azido-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] . Azido-PEG6-alcohol is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2] .
IC50 & Target
|
PEGs |
Non-cleavable |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins
[1]
.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
Synonyms