[CAS NO. 88903-69-9] Xestospongin C

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PRODUCTS SPECIFICATIONS [88903-69-9]

Catalog

AS993028

Brand

Arctom Scientific

CAS

88903-69-9

DESCRIPTION [88903-69-9]

Overview

MDL	-
Molecular Weight	446.71
Molecular Formula	C28H50N2O2
SMILES	[H][C@]1([C@](CCCCCC[C@@](CCN2CCC3)([H])O[C@@]2([H])[C@]3([H])CCCCCC4)([H])CCC5)N5CC[C@]4([H])O1

For research use only. We do not sell to patients.

Summary

Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca ²⁺ release from cerebellar microsomes with an IC ₅₀ of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca ²⁺ signaling in neuronal and nonneuronal cells ^[1] ^[2] ^[3] .

IC50 & Target

IP3R

In Vitro

Xestospongin C (XeC; 10 μM; 1 h before Aβ) pretreatment before Aβ _1-42 (20 μM; 24 hours) application displays a significant decrease in the early apoptotic rate (9.87%) compared to the Aβ alone treated group (18.38%) ^[1] .
Xestospongin C (10 μM; 1 h before Aβ) and Aβ _1-42 (20 μM; 100 s) has significant main effects on the peak value and average values of Ca ²⁺ changes, as well as a significant interaction in primary cultured hippocampal neurons ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Xestospongin C (3 μM; intracerebroventrical injection by a pump for four weeks) ameliorates the disinhibition-like behavior and long term spatial memory deficits of 8-month-old male APP/PS1 mice of Alzheimer's disease ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Viscous liquid

Source

a marine sponge, Xestospongia sp.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

References

Synonyms

5H,17H-1,23:11,13-Diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b′]dipyridine, eicosahydro-, (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-

5H,17H-1,23:11,13-Diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b′]dipyridine, eicosahydro-, [1R-(1R*,4aR*,11R*,12aS*,13S*,16aS*,23R*,24aS*)]-

(1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b′]dipyridine

Xestospongin C

Xestospongine C

(-)-Xestospongin C

Araguspongin E

(-)-Araguspongin E

Araguspongine E

(-)-Araguspongine E