[CAS NO. 2734858-36-5]  2',3'-cGAMP sodium

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PRODUCTS SPECIFICATIONS [2734858-36-5]

Store
Catalog
HY-100564A
Brand
MCE
CAS
2734858-36-5

DESCRIPTION [2734858-36-5]

Overview

MDL-
Molecular Weight718.37
Molecular FormulaC20H22N10Na2O13P2
SMILESOC1([H])[C@](OP(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)(O[Na])=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O[Na])=O

For research use only. We do not sell to patients.


Summary

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ) . 2',3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm [1] .


IC50 & Target

Human Endogenous Metabolite


In Vitro

2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)


Solvent & Solubility

In Vitro:

H 2 O : 50 mg/mL ( 69.60 mM ; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3920 mL 6.9602 mL 13.9204 mL
5 mM 0.2784 mL 1.3920 mL 2.7841 mL
10 mM 0.1392 mL 0.6960 mL 1.3920 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: PBS

    Solubility: 18.33 mg/mL (25.52 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.