[CAS NO. 187389-53-3] Boc-Asp(OMe)-fluoromethyl ketone
PRODUCTS SPECIFICATIONS [187389-53-3]
DESCRIPTION [187389-53-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 263.26 |
| Molecular Formula | C11H18FNO5 |
| SMILES | O=C(OC)C[C@H](NC(OC(C)(C)C)=O)C(CF)=O |
Summary
Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8 [1] [2] .
IC50 & Target
|
Caspase |
In Vitro
Boc-Asp(OME)-Fluoromethyl Keton (100 μM; 30 minutes; Polymorphonuclear leukocytes) prevents Fas-induced and spontaneous apoptosis (−CH-11) [1] . Boc-Asp(OME)-Fluoromethyl Keton (20 μM; 5 hours; J774.1/JA-4 cells) significantly increases LDH release [2] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 379.85 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7985 mL | 18.9926 mL | 37.9853 mL |
| 5 mM | 0.7597 mL | 3.7985 mL | 7.5971 mL |
| 10 mM | 0.3799 mL | 1.8993 mL | 3.7985 mL |
References
- [1] Paunel-Görgülü A, et al. Stimulation of Fas signaling down-regulates activity of neutrophils from major trauma patients with SIRS. Immunobiology. 2011;216(3):334-342.
- [2] Koike A, et al. Pan-caspase inhibitors induce necroptosis via ROS-mediated activation of mixed lineage kinase domain-like protein and p38 in classically activated macrophages. Exp Cell Res. 2019;380(2):171-179.