Orexin A (human, rat, mouse) (TFA)
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 3675.12 |
| Molecular Formula | C2HF3O2 |
| SMILES | - |
3 Publications Citing Use of MCE
Summary
Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA is a specific, high-affinity agonist for G-protein-coupled receptor OX1R . Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats [1] [2] .
IC50 & Target
|
OX 1 Receptor |
In Vitro
Orexin A (human, rat, mouse) TFA has high affinity for OX1R, with 38 nM IC 50 and 34 nM EC 50 values in the the [Ca 2﹢ ]i transient assay [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Orexin A (human, rat, mouse) TFA (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the latency to response at 10 and 30 mg/kg i.v. when given 5 min pre-test from 24.8±2.0 s in vehicle-treated mice to 35.0±3.7 s and 45.7±4.5 s, respectively
[2]
.
Orexin A (human, rat, mouse) TFA (3, 10 and 30 mg/kg; i.v.) is given immediately before phenylp-quinone (PPQ) and increases the latency to the first PPQ-induced constriction from 357.4±35.2 s in vehicle-treated mice to 500.3±31.2 s at 10 mg/kg and 594.5±5.5 s at 30 mg/kg
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Female mice (mouse carrageenan-induced thermal hyperalgesia test [2] |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | i.v.; 5 min pre-test |
| Result: | Significantly increased the latency to response at 10 and 30 mg/kg. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 27.21 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.2721 mL | 1.3605 mL | 2.7210 mL |
| 5 mM | 0.0544 mL | 0.2721 mL | 0.5442 mL |
| 10 mM | 0.0272 mL | 0.1360 mL | 0.2721 mL |
References
