- Cart - 0 item(s)
- $0.00
Your shopping cart is empty!
- Chemistry
- Inhibitors
- Natural Products
- Alkaloids
- Amino acid
- Anthraquinones
- Cerebrosides
- Chalcones
- Coumarins
- Diterpenoids
- Flavonoids
- Iridoids
- Lignans
- Lipids
- Miscellaneous
- Monoterpenoids
- Other terpenes
- Phenols
- Phenylpropanoids
- Quinones
- Saccharides
- Sesquiterpenoids
- Steroids
- Tetraterpenoids
- Thiophenes
- Triterpenoids
- Xanthones
- Polyphenols
- Stibene glucosides
- Oligose
- Anthocyanins
- Miscellaneous
- Chromones
- Terpenoids
- Indoles
- Procyanidins
- Aliphatics
- Botanical Cyclopeptides
- ADCs
- Antibodies
- Multiplex IHC
- Material Science
- Others
[CAS NO. 441785-24-6] LB80317
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-106235 |
| Brand: | MCE |
| CAS: | 441785-24-6 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 315.22 |
| Molecular Formula | C10H14N5O5P |
| SMILES | OP(O)(COC1(CN2C=NC3=C2N=C(N)NC3=O)CC1)=O |
Summary
IC50 & Target
EC50: 0.5 μM (DNA synthesis of HBV) [2]
In Vitro
After phosphorylation to di- and triphosphate forms, LB80317 is incorporated into the viral DNA inside the nucleocapsid, which inhibits further DNA synthesis. In in vitro studies using cell line models, the drug concentrations causing 50% reduction in HBV DNA produced (EC 50 ) is 0.5 μM for LB80317 [2] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
LB80317 Related Antibodies
- CDT1 Antibody
- Hes1 Antibody
- JunB Antibody
- Nanog Antibody
- PCNA Antibody
- S100A4 Antibody
- SP1 Antibody
- BRCA1 Antibody (YA819)
- Elongation Factor 1A1 Antibody
- KAP1 Antibody
- MCM2 Antibody (YA705)
- MLH1 Antibody (YA703)
- RNA Polymerase II Subunit B1 Antibody
- RPA70 Antibody (YA678)
- MCM2 Antibody
- MLH1 Antibody
- PDX1 Antibody
- RbAP48 Antibody
- RbBP5 Antibody
- Argonaute 2 Antibody (YA612)
- S100A6 Antibody (YA674)
In Vivo
Forty percent of the amount of LB80331/LB80317 in the mouse liver is detected as the phosphorylated form. LB80380 is rapidly absorbed and converted to LB80331. LB80317 has a long half-life at steady-state (T 1/2 =8.3-9.9 hours) [1] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Man-Fung Yuen, et al. Pharmacokinetics of LB80331 and LB80317 Following Oral Administration of LB80380, a New Antiviral Agent for Chronic Hepatitis B (CHB), in Healthy Adult Subjects, CHB Patients, and Mice. Antimicrob Agents Chemother. 2009 May;53(5):177
- [2] Lung-Yi Mak, et al. Pharmacokinetic Evaluation of Besifovir for the Treatment of HBV Infection. Expert Opin Drug Metab Toxicol. 2018 Jan;14(1):101-106.
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.