BIO-11006 acetate
PRODUCTS SPECIFICATIONS
DESCRIPTION
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1110.22 |
| Molecular Formula | C48H79N13O17 |
| SMILES | - |
Summary
BIO-11006 acetate, an analog of the MANS peptide, is a MARCKS (myristoylated alanine-rich C kinase substrate) inhibitor [1] .
IC50 & Target
Myristoylated alanine-rich C kinase substrate [1]
In Vivo
Inhaled, aerosolized BIO-11006 acetate attenuates LPS-induced neutrophil influx into the lung, activation of NF-κB, and expression of the proinflammatory cytokines, KC and TNF-α, and thus reverses the development of lung injury in mice instilled intratracheally with LPS [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00648245 | BioMarck Pharmaceuticals, Ltd.|National Heart, Lung, and Blood Institute (NHLBI) |
COPD|Chronic Obstructive Pulmonary Disease
|
June 2008 | Phase 2 |
| NCT04183062 | Nicklaus Children´s Hospital f+k+a Miami Children´s Hospital |
Osteosarcoma Metastatic|Ewing´s Sarcoma Metastatic
|
October 4, 2019 | Phase 2 |
| NCT03202394 | BioMarck Pharmaceuticals, Ltd. |
Respiratory Distress Syndrome, Adult
|
August 5, 2017 | Phase 2 |
| NCT03472053 | BioMarck Pharmaceuticals, Ltd. |
Non Small Cell Lung Cancer Stage IIIB
|
February 1, 2018 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 50 mg/mL ( 45.04 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.9007 mL | 4.5036 mL | 9.0072 mL |
| 5 mM | 0.1801 mL | 0.9007 mL | 1.8014 mL |
| 10 mM | 0.0901 mL | 0.4504 mL | 0.9007 mL |
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1.
Add each solvent one by one: PBS
Solubility: 20 mg/mL (18.01 mM); Clear solution; Need ultrasonic
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2.
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3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution