- Cart - 0 item(s)
- $0.00
Your shopping cart is empty!
- Chemistry
- Inhibitors
- Anti-infection
- Apoptosis
- Autophagy
- Cell Cycle/DNA Damage
- Cytoskeleton
- Epigenetics
- GPCR/G Protein
- Immunology/Inflammation
- JAK/STAT Signaling
- MAPK/ERK Pathway
- Membrane Transporter/Ion Channel
- Metabolic Enzyme/Protease
- Neuronal Signaling
- NF-κB
- PI3K/Akt/mTOR
- PROTAC
- Protein Tyrosine Kinase/RTK
- Stem Cell/Wnt
- TGF-beta/Smad
- Vitamin D Related/Nuclear Receptor
- Others
- Methylation
- Cytoskeletal Signaling
- Natural Products
- Alkaloids
- Amino acid
- Anthraquinones
- Cerebrosides
- Chalcones
- Coumarins
- Diterpenoids
- Flavonoids
- Iridoids
- Lignans
- Lipids
- Miscellaneous
- Monoterpenoids
- Other terpenes
- Phenols
- Phenylpropanoids
- Quinones
- Saccharides
- Sesquiterpenoids
- Steroids
- Tetraterpenoids
- Thiophenes
- Triterpenoids
- Xanthones
- Polyphenols
- Stibene glucosides
- Oligose
- Anthocyanins
- Miscellaneous
- Chromones
- Terpenoids
- Indoles
- Procyanidins
- Aliphatics
- Botanical Cyclopeptides
- ADCs
- Antibodies
- Multiplex IHC
- Material Science
- Others
[CAS NO. ] BIO-11006 acetate
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-106377A |
| Brand: | MCE |
| CAS: | - |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 1110.22 |
| Molecular Formula | C48H79N13O17 |
| SMILES | - |
Summary
BIO-11006 acetate, an analog of the MANS peptide, is a MARCKS (myristoylated alanine-rich C kinase substrate) inhibitor [1] .
IC50 & Target
Myristoylated alanine-rich C kinase substrate [1]
In Vivo
Inhaled, aerosolized BIO-11006 acetate attenuates LPS-induced neutrophil influx into the lung, activation of NF-κB, and expression of the proinflammatory cytokines, KC and TNF-α, and thus reverses the development of lung injury in mice instilled intratracheally with LPS [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00648245 | BioMarck Pharmaceuticals, Ltd.|National Heart, Lung, and Blood Institute (NHLBI) |
COPD|Chronic Obstructive Pulmonary Disease
|
June 2008 | Phase 2 |
| NCT04183062 | Nicklaus Children´s Hospital f+k+a Miami Children´s Hospital |
Osteosarcoma Metastatic|Ewing´s Sarcoma Metastatic
|
October 4, 2019 | Phase 2 |
| NCT03202394 | BioMarck Pharmaceuticals, Ltd. |
Respiratory Distress Syndrome, Adult
|
August 5, 2017 | Phase 2 |
| NCT03472053 | BioMarck Pharmaceuticals, Ltd. |
Non Small Cell Lung Cancer Stage IIIB
|
February 1, 2018 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Sealed storage, away from moisture
| Powder | -80°C | 2 years |
|---|---|---|
| -20°C | 1 year |
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 50 mg/mL ( 45.04 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 0.9007 mL | 4.5036 mL | 9.0072 mL |
| 5 mM | 0.1801 mL | 0.9007 mL | 1.8014 mL |
| 10 mM | 0.0901 mL | 0.4504 mL | 0.9007 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 20 mg/mL (18.01 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.