[CAS NO. 1092551-88-6] Omzotirome
PRODUCTS SPECIFICATIONS [1092551-88-6]
DESCRIPTION [1092551-88-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 328.41 |
| Molecular Formula | C19H24N2O3 |
| SMILES | CC1=CC(CC2=C(N(CCC(O)=O)N=C2C)C)=C3C(CCC3)=C1O |
Summary
In Vivo
Omzotirome (0.750 mg/ 100 g; i.p.) with high-fat diet rats have significantly less visceral adipose tissue (vs. HFD rats) and exhibit altered metabolism in two major tissues that are very active metabolically and exhibit increased energy expenditure and body weight (BW) gain comparable to that of standard chow-fed rats
[1]
.
Omzotirome, a functional analog of iodothyronines, reduces adiposity by increasing energy expenditure and fatty acid oxidation in rats receiving a high-fat diet (HFD)
[1]
.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Wistar rats (8 weeks) [1] |
| Dosage: | 0.750 mg/ 100 g |
| Administration: | I.p. |
| Result: | With high-fat diet rats had significantly less visceral adipose tissue (vs. HFD rats) and exhibited altered metabolism in two major tissues that were very active metabolically and exhibited increased energy expenditure and body weight (BW) gain comparable to that of standard chow-fed rats. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01408667 | Torrent Pharmaceuticals Limited |
Metabolic Cardiovascular Syndrome
|
November 2011 | Phase 1|Phase 2 |
| NCT03254446 | Torrent Pharmaceuticals Limited|Iqvia Pty Ltd |
Diabetes|Dyslipidemias|Hypertension
|
March 12, 2018 | Phase 3 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL ( 304.50 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.0450 mL | 15.2249 mL | 30.4497 mL |
| 5 mM | 0.6090 mL | 3.0450 mL | 6.0899 mL |
| 10 mM | 0.3045 mL | 1.5225 mL | 3.0450 mL |
References
