[CAS NO. 2450268-84-3] WAY-213613 hydrochloride

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Catalog:	HY-107523A
Brand:	MCE
CAS:	2450268-84-3

Overview

MDL	-
Molecular Weight	451.65
Molecular Formula	C16H14BrClF2N2O4
SMILES	BrC(C=C(F)C(F)=C1)=C1OC2=CC=C(NC(C[C@H](N)C(O)=O)=O)C=C2.Cl

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

[1]Nat Commun. 2022 Jun 9;13(1):3329.
[2]Ann Transl Med. 2020 Jun;8(11):691.

Summary

WAY-213613 (hydrochloride) is a potent and selective human EAAT2 inhibitor. WAY-213613 has potent EAAT2 inhibitory activity with an IC ₅₀ value of 85 nM. WAY-213613 can be used for the research of central nervous system ^[1] .

IC50 & Target

IC50: 5004 nM (EAAT1); 85 nM (EAAT2); 3787 nM (EAAT3) ^[1]

In Vitro

WAY-213613 (hydrochloride) (0-100 μM) has inhibitory activity for human EAAT1, EAAT2 and EAAT3 subtype with IC ₅₀ values of 5004 nM, 85 nM and 3787 nM, respectively ^[1] .
WAY-213613 (3, 30, 300 nM) has the inhibitory effect on synaptosomal L-[ ³ H] glutamate uptake with K _i values of 15 nM, 41 nM and 55 nM in the presence of 3, 30 and 300 nM, respectively ^[1] .
WAY-213613 (0-100 μM) produces a concentration-dependent block of glutamate-induced currents in EAAT1-, EAAT2- or EAAT3-injected oocytes, with IC ₅₀ values of 48, 0.13 and 4.0 μM, respectively ^[1] .
WAY-213613 (0.5–50 μM) exhibits good selectivity over ionotropic receptors and EAAT2 and potent activity toward blocking NMDA-stimulated responses ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 110.71 mM ; warming and heat to 80°C)

H ₂ O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2141 mL	11.0705 mL	22.1410 mL
5 mM	0.4428 mL	2.2141 mL	4.4282 mL
10 mM	0.2214 mL	1.1071 mL	2.2141 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13.
[2] Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9(8):e102136.

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