[CAS NO. 24570-49-8] Muscarine iodide
PRODUCTS SPECIFICATIONS [24570-49-8]
DESCRIPTION [24570-49-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 301.17 |
| Molecular Formula | C9H20INO2 |
| SMILES | C[N+](C)(C)C[C@@H]1C[C@@H](O)[C@H](C)O1.[I-] |
Summary
Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist [1] [2] .
In Vitro
Muscarine iodide administration (100 µM) induces an intracellular calcium signal amplitude similar to the one triggered by 10 µM ACh
[1]
.
Muscarine iodide (1-30 μM) produces a dose-dependent hyperpolarization in a sub-population of the NRM cells that contain 5-hydroxytryptamine (5-HT) on the NRM neurons
[2]
.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 50 mg/mL ( 166.02 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3204 mL | 16.6019 mL | 33.2038 mL |
| 5 mM | 0.6641 mL | 3.3204 mL | 6.6408 mL |
| 10 mM | 0.3320 mL | 1.6602 mL | 3.3204 mL |
References
- [1] Beatrice Mihaela Radu, et al. All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium. Sci Rep. 2017 Jul 11;7(1):5083.
- [2] Z Z Pan, et al. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci. 1994 Mar;14(3 Pt 1):1332-8.