[CAS NO. 2749300-35-2] WDR5-IN-4TFA
PRODUCTS SPECIFICATIONS [2749300-35-2]
DESCRIPTION [2749300-35-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 612.40 |
| Molecular Formula | C27H23Cl2F4N5O3 |
| SMILES | ClC1=CC=C(CNC(C2=CC(CN3C(N(C)C=C3)=N)=CC(C4=C(C)N=C(F)C=C4)=C2)=O)C=C1Cl.O=C(O)C(F)(F)F |
Summary
WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 ( WDR5 ), with a K d of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
DMSO : ≥ 250 mg/mL ( 408.23 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6329 mL | 8.1646 mL | 16.3292 mL |
| 5 mM | 0.3266 mL | 1.6329 mL | 3.2658 mL |
| 10 mM | 0.1633 mL | 0.8165 mL | 1.6329 mL |
