[CAS NO. 1613458-78-8] GSK-2793660

Name: GSK-2793660
Brand: Arctom Scientific
SKU: HY-112318A

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PRODUCTS SPECIFICATIONS [1613458-78-8]

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Catalog

HY-112318A

Brand

MCE

CAS

1613458-78-8

DESCRIPTION [1613458-78-8]

Overview

MDL	-
Molecular Weight	393.91
Molecular Formula	C20H28ClN3O3
SMILES	NC1(C(N[C@@H](CC)/C=C/C(N2CCC3=C2C=CC=C3)=O)=O)CCOCC1.[H]Cl

For research use only. We do not sell to patients.

Summary

GSK-2793660 is an orally active and irreversible inhibitor of Cathepsin C ( CTSC ). GSK-2793660 can be used for the research of bronchiectasis ^[1] ^[2] .

IC50 & Target

Cathepsin C (CTSC) ^[1] ^[2]

In Vivo

GSK-2793660 is a cathepsin C (also known as dipeptidyl peptidase I enzyme) inhibitor for the reaearch of cystic fibrosis, non-cystic fibrosis bronchiectasis, anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis and bronchiectasis ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02058407	GlaxoSmithKline	Bronchiectasis	January 28, 2014	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 253.87 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5387 mL	12.6933 mL	25.3865 mL
5 mM	0.5077 mL	2.5387 mL	5.0773 mL
10 mM	0.2539 mL	1.2693 mL	2.5387 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (6.35 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.35 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.35 mM); Clear solution

* All of the co-solvents are available by MCE.