[CAS NO. 1638-41-1] p38 MAP Kinase Inhibitor IV

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PRODUCTS SPECIFICATIONS [1638-41-1]

Catalog

HY-112401

Brand

MCE

CAS

1638-41-1

DESCRIPTION [1638-41-1]

Overview

MDL	-
Molecular Weight	456.94
Molecular Formula	C12H4Cl6O4S
SMILES	OC1=C(Cl)C=C(Cl)C(Cl)=C1S(=O)(C2=C(O)C(Cl)=CC(Cl)=C2Cl)=O

For research use only. We do not sell to patients.

Summary

p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC ₅₀ s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively ^[1] .

IC50 & Target

p38α

0.13 μM (IC ₅₀ )

p38β

0.55 μM (IC ₅₀ )

p38δ

8.63 μM (IC ₅₀ )

p38χ

5.47 μM (IC ₅₀ )

In Vitro

p38 MAP Kinase Inhibitor IV (MT4) shows IC ₅₀ values of 0.13, 0.55, 5.47, and 8.63μM for p38α , β, χ, andδ, respectively. p38 MAP Kinase Inhibitor IV has the suppressive action on the release of TNF-alpha and IL-1beta in PBMC with IC50 values of 22 and 44 nM, respectively ^[1] .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Liu YC, et al. Identification of a novel competitive inhibitor of p38alpha MAPK by a human PBMC screen. Biochem Biophys Res Commun. 2007;352(3):656-661.