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[CAS NO. ] Gln-AMSTFA
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-112861A |
| Brand: | MCE |
| CAS: | - |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 588.47 |
| Molecular Formula | C17H23F3N8O10S |
| SMILES | NC1=C2N=CN([C@@H]3O[C@H](COS(=O)(NC([C@@H](N)CCC(N)=O)=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1.OC(C(F)(F)F)=O |
Summary
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a K i of 1.32 µM.
IC50 & Target
Ki: 1.32 µM (GlnRS) [1]
In Vitro
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
H 2 O : 130 mg/mL ( 220.91 mM ; Need ultrasonic)
DMSO : 50 mg/mL ( 84.97 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6993 mL | 8.4966 mL | 16.9932 mL |
| 5 mM | 0.3399 mL | 1.6993 mL | 3.3986 mL |
| 10 mM | 0.1699 mL | 0.8497 mL | 1.6993 mL |
References
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