[CAS NO. ] Gln-AMSTFA

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PRODUCTS SPECIFICATIONS

Catalog

HY-112861A

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	588.47
Molecular Formula	C17H23F3N8O10S
SMILES	NC1=C2N=CN([C@@H]3O[C@H](COS(=O)(NC([C@@H](N)CCC(N)=O)=O)=O)[C@@H](O)[C@H]3O)C2=NC=N1.OC(C(F)(F)F)=O

For research use only. We do not sell to patients.

Summary

Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. Gln-AMS inhibits glutaminyl-tRNA synthetase (GlnRS) with a K _i of 1.32 µM.

IC50 & Target

Ki: 1.32 µM (GlnRS) ^[1]

In Vitro

Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

H ₂ O : 130 mg/mL ( 220.91 mM ; Need ultrasonic)

DMSO : 50 mg/mL ( 84.97 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6993 mL	8.4966 mL	16.9932 mL
5 mM	0.3399 mL	1.6993 mL	3.3986 mL
10 mM	0.1699 mL	0.8497 mL	1.6993 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 4.25 mg/mL (7.22 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.25 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.25 mM); Clear solution

* All of the co-solvents are available by MCE.