[CAS NO. ] (Rac)-GSK547

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PRODUCTS SPECIFICATIONS

Catalog

HY-114492A

Brand

MCE

CAS

-

DESCRIPTION

Overview

MDL	-
Molecular Weight	396.39
Molecular Formula	C20H18F2N6O
SMILES	N#CC1=NC=NC(N2CCC(C(N3N=CCC3C4=CC(F)=CC(F)=C4)=O)CC2)=C1

For research use only. We do not sell to patients.

Summary

(Rac)-GSK547 is the racemate of GSK547. GSK547 is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL ( 315.35 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5228 mL	12.6138 mL	25.2277 mL
5 mM	0.5046 mL	2.5228 mL	5.0455 mL
10 mM	0.2523 mL	1.2614 mL	2.5228 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Wang W, et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 2018 Nov 12;34(5):757-774.e7.