[CAS NO. 21200-24-8] Indolmycin
PRODUCTS SPECIFICATIONS [21200-24-8]
DESCRIPTION [21200-24-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 257.29 |
| Molecular Formula | C14H15N3O2 |
| SMILES | O=C1N=C(NC)O[C@H]1[C@@H](C2=CNC3=C2C=CC=C3)C |
Summary
Indolmycin (TAK-083), an antibiotic , is a competitive inhibitor of prokaryotic tryptophanyl-tRNA synthetase (TrpS) . Indolmycin (TAK-083) possesses both anti-viral and anti-bacterial activity [1] [2] [3] .
In Vitro
Indolmycin was bacteriostatic and demonstrated good activity against MSSA (methicillinsusceptible Staphylococcus aureus), MRSA (methicillin-resistant S. aureus) and VISA (vancomycinintermediate S. aureus), including strains resistant to mupirocin or fusidic acid. Indolmycin MICs for 20 strains ranged from 8 to 32 mg/L, whereas a single strain exhibited high-level resistance (MIC 128 mg/L) [2] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] R G Werner, et al. Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase. Eur J Biochem. 1976 Sep;68(1):1-3.
- [2] Julian G Hurdle, et al. Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections. J Antimicrob Chemother. 2004 Aug;54(2):549-52.
- [3] M R Harnden, et al. Thiazolinone analogues of indolmycin with antiviral and antibacterial activity. J Med Chem. 1978 Jan;21(1):82-7.
