[CAS NO. 2448471-08-5] CM-579trihydrochloride
PRODUCTS SPECIFICATIONS [2448471-08-5]
DESCRIPTION [2448471-08-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 602.04 |
| Molecular Formula | C29H43Cl3N4O3 |
| SMILES | CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1.Cl.Cl.Cl |
Summary
IC50 & Target
|
DNA Methyltransferase 32 nM (IC 50 ) |
DNMT1 1.5 nM (Kd) |
DNMT3A 92 nM (IC 50 ) |
DNMT3B 1000 nM (IC 50 ) |
G9a 16 nM (IC 50 ) |
In Vitro
The K d of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC 50 s of 92 nM and 1000 nM, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
H 2 O : 37.5 mg/mL ( 62.29 mM ; Need ultrasonic)
DMSO : 33.33 mg/mL ( 55.36 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.6610 mL | 8.3051 mL | 16.6102 mL |
| 5 mM | 0.3322 mL | 1.6610 mL | 3.3220 mL |
| 10 mM | 0.1661 mL | 0.8305 mL | 1.6610 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 16.67 mg/mL (27.69 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (4.15 mM); Clear solution
